Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 797154..797811 Replicon chromosome
Accession NZ_CP061842
Organism Klebsiella pneumoniae strain HC139

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IEY90_RS04025 Protein ID WP_002916310.1
Coordinates 797401..797811 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IEY90_RS04020 Protein ID WP_002916312.1
Coordinates 797154..797420 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IEY90_RS03995 792310..793743 - 1434 WP_009485881.1 6-phospho-beta-glucosidase BglA -
IEY90_RS04000 793862..794590 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IEY90_RS04005 794640..794951 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IEY90_RS04010 795115..795774 + 660 WP_002916317.1 hemolysin III family protein -
IEY90_RS04015 795925..796908 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
IEY90_RS04020 797154..797420 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IEY90_RS04025 797401..797811 + 411 WP_002916310.1 protein YgfX Toxin
IEY90_RS04030 797818..798339 - 522 WP_002916308.1 flavodoxin FldB -
IEY90_RS04035 798440..799336 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IEY90_RS04040 799359..800072 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IEY90_RS04045 800078..801811 + 1734 WP_032105216.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T173085 WP_002916310.1 NZ_CP061842:797401-797811 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T173085 NZ_CP080095:c233274-232996 [Paraburkholderia edwinii]
ATGATCGAATCGTTTCGATGCAAAGATACCGAAGCCCTTTACAAGGGCGAGTCGCCGAAGCGGTTCCGGTCGATTGAGTC
CGTTGCCGTGCGCAAGCTTCAGATGCTCGAAGCGGCCCATGAGCTAAAAGACTTGCGCGCACCGCCAGGCAACAGGCTCG
AGCCGCTGCACGGAAATCGGACGAATCGGCACAGCATCCGTATCAACGGGCAATGGCGCATCTGTTTCGTCTGGACGAGC
GACGGTGCGACTGAGGTCGAAATTATCGACTACCACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT173085 WP_002916312.1 NZ_CP061842:797154-797420 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT173085 NZ_CP080095:c232983-232681 [Paraburkholderia edwinii]
ATGGTCAAGAACGGAATGCGCGCAGTCCACCCGGGCGAAGTCCTGCGGGAGGAGTTCCTCGTCCCGCTGGAAATGAGCGT
GAATGCGCTATCGCTGGCGCTGAGCGTGCCCTCCACGCGGCTGCACGAAATCGTGAACGAGCGGCGTGGCATCACGGCCG
ATACCGCCTATCGGCTCGCTCGCTATTTCGACACAACGCCCGAATTCTGGCTGAACCTCCAGATCGCCTATGACCTGAAG
ACGCTGCCGACGCGCGCAGAGATCGACCGCAAGGTGGAGCCGCGCGAATCGGCGGGCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References