Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 49385..49913 Replicon plasmid unnamed
Accession NZ_CP061841
Organism Legionella pneumophila subsp. pneumophila strain AW-13-4

Toxin (Protein)


Gene name relE Uniprot ID A0A0A8UYT5
Locus tag IF130_RS15960 Protein ID WP_011212544.1
Coordinates 49626..49913 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A0A8UU85
Locus tag IF130_RS15955 Protein ID WP_011212545.1
Coordinates 49385..49636 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IF130_RS15930 45074..45955 + 882 WP_021436862.1 hypothetical protein -
IF130_RS15935 46243..46821 + 579 WP_010655397.1 nucleotidyltransferase domain-containing protein -
IF130_RS15940 46808..47245 + 438 WP_010655396.1 DNA-binding protein -
IF130_RS15945 47229..48050 + 822 WP_011212547.1 DUF4111 domain-containing protein -
IF130_RS15950 48669..49136 + 468 WP_011212546.1 hypothetical protein -
IF130_RS15955 49385..49636 + 252 WP_011212545.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
IF130_RS15960 49626..49913 + 288 WP_011212544.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IF130_RS15965 50126..50887 + 762 WP_011212543.1 MerR family transcriptional regulator -
IF130_RS15970 50945..51820 + 876 WP_011212542.1 alpha/beta hydrolase -
IF130_RS15975 51914..52096 - 183 WP_011212541.1 hypothetical protein -
IF130_RS15980 52152..52463 - 312 WP_011212540.1 hypothetical protein -
IF130_RS15985 52472..53047 - 576 WP_011212539.1 pyridoxamine 5'-phosphate oxidase family protein -
IF130_RS15990 53098..54606 - 1509 WP_011212538.1 DUF3987 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid blaOXA-29 - 1..129883 129883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(8-68)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11302.35 Da        Isoelectric Point: 10.4380

>T173082 WP_011212544.1 NZ_CP061841:49626-49913 [Legionella pneumophila subsp. pneumophila]
MIYELHFHPLALKEWKKLSKELQEQFKKLLKRRLENPHVISAKLSGHLKDCYKIKLHQAGYRLVYQVNDNKMILLVVAVG
KRNKNKVYESAEDRT

Download         Length: 288 bp

>T173082 NZ_CP080093:c20599-20318 [Salmonella enterica]
ATGACCTATGAACTGGCTTTTGACCGCAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATATCAAGTCATTGATGAGAAAGTTGTTTTACTCGTTATTGCTGTTGGAAGA
AGGGAAAGCAGCGAAGTTTATCAGATTGCAGATATGCGCTAA

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9165.58 Da        Isoelectric Point: 4.5164

>AT173082 WP_011212545.1 NZ_CP061841:49385-49636 [Legionella pneumophila subsp. pneumophila]
MQTLYATQVASISELKKNPTKLINDAHGMPVVILNHNVAAAYLIPAETFEKLMDAVDESELKSIVEQRLSEPFTPVKVAL
DDL

Download         Length: 252 bp

>AT173082 NZ_CP080093:c20840-20589 [Salmonella enterica]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0A8UYT5

Antitoxin

Source ID Structure
AlphaFold DB A0A0A8UU85

References