Detailed information of TA system TA173079

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1809068..1809729
• Replicon: chromosome
• Accession: NZ_CP061839
• Organism: Treponema pedis strain KS1

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7S6WMI4
• Locus tag: IFE08_RS08275
• Protein ID: WP_029410768.1
• Coordinates: 1809298..1809729 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: IFE08_RS08270
• Protein ID: WP_194075506.1
• Coordinates: 1809068..1809298 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFE08_RS08260	1804328..1806703	+	2376	WP_194075503.1	4Fe-4S cluster-binding domain-containing protein	-
IFE08_RS08265	1806822..1808876	+	2055	WP_194075505.1	DUF87 domain-containing protein	-
IFE08_RS08270	1809068..1809298	+	231	WP_194075506.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
IFE08_RS08275	1809298..1809729	+	432	WP_029410768.1	type II toxin-antitoxin system VapC family toxin	Toxin
IFE08_RS08280	1809918..1811141	+	1224	WP_194075508.1	integron integrase	-
IFE08_RS08285	1811498..1813564	+	2067	WP_194077659.1	HAMP domain-containing protein	-
IFE08_RS08290	1813818..1814051	+	234	WP_029410340.1	hypothetical protein	-
IFE08_RS08295	1814035..1814451	+	417	WP_024468129.1	PIN domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integron	-	-	1798818..1811141	12323

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-124)

Antitoxin

• SpoVT-AbrB domain (7-46)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16308.84 Da
• Isoelectric Point: 8.2567

>T173079 WP_029410768.1 NZ_CP061839:1809298-1809729 [Treponema pedis]
MYLLDTNICIFLIKNKNLHLKKKIFNCKKEELFLSSITIAELEYGVAKSQFREKNRHALLDFCSDFTNIIGFTTEDTETY
GMIRAYLENKGIPIGPFDTQIAAQGLARNLTVVTNNIKEFSRIPGLKVEDWTKNNINLTPAST

Nucleotide

• Length: 432 bp

>T173079 NZ_CP080091:c4489572-4489261 [Salmonella enterica]
ATGCAATTTATAGAAACGGAACTCTTTACTGAAGATGTTAAAAAACTGCTCGATGAGGATGAATACCATAAGCTTCAGGT
TTTTATGGCTCAGCATCCAGATTGTGGTGATGTCATTCAGGAAACGGGCGGCCTGAGAAAAATGCGCTGGGGAGCGCGAG
GCAAAGGAAAGCGTAGTGGCGTGCGAATTATCTATTTTCACCGTAGTCAACGGTATGAGATTCGCTTGCTTCTGATTTAT
CAAAAAGGCATTAAAGATGATCTCACGCCGCAGGAAAAAGCGGTGCTTCGTATGCTGAATGAGAGGTGGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8714.89 Da
• Isoelectric Point: 5.8148

>AT173079 WP_194075506.1 NZ_CP061839:1809068-1809298 [Treponema pedis]
MVCAKVFTSGNSQAVRIPKEFHIDFSELFIKKIGSSIILTPKESNWENLERSLSEFSDDFMTKGRSQPATQEREVF

Nucleotide

• Length: 231 bp

>AT173079 NZ_CP080091:c4489260-4488970 [Salmonella enterica]
ATGGATAAAGTGTTATTTGAGCGATTAACTCAAAGTATGTCTCAAATGAATGAAATCATTGAAGGGACCCGTGAGCCTTC
TCGTACCTTTCATATTGATGCAATGAAGATTAAAGAAATACGGCAGGCATCTGGGTTGTCGCAATCTAAGTTTGCAGAAC
TGATTTCGGTCAACGTGGATACGCTGCGCAACTGGGAGCAAGGAAGACGTTCACCGACAGGGCCAGCCAAAGCGTTACTT
CGCGCCATTGCCAACGACCCGAGAAACGTTATACAAGCATTGCGTTATTGA

Structures

Toxin

• AlphaFold DB: A0A7S6WMI4