Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 4925759..4926560 Replicon chromosome
Accession NZ_CP061832
Organism Klebsiella pneumoniae strain C0674

Toxin (Protein)


Gene name yeeV Uniprot ID -
Locus tag IFX77_RS24040 Protein ID WP_064143481.1
Coordinates 4926183..4926560 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag IFX77_RS24035 Protein ID WP_064143482.1
Coordinates 4925759..4926136 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFX77_RS24010 4923184..4923417 + 234 WP_001117568.1 DUF905 family protein -
IFX77_RS24015 4923508..4924326 + 819 WP_001610805.1 DUF945 domain-containing protein -
IFX77_RS24020 4924418..4924903 + 486 WP_000214414.1 antirestriction protein -
IFX77_RS24025 4924919..4925395 + 477 WP_110225547.1 RadC family protein -
IFX77_RS24030 4925458..4925679 + 222 WP_110225546.1 DUF987 domain-containing protein -
IFX77_RS24035 4925759..4926136 + 378 WP_064143482.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IFX77_RS24040 4926183..4926560 + 378 WP_064143481.1 TA system toxin CbtA family protein Toxin
IFX77_RS24045 4926557..4926754 + 198 Protein_4712 hypothetical protein -
IFX77_RS24050 4926782..4926979 + 198 WP_023563519.1 DUF957 domain-containing protein -
IFX77_RS24055 4927064..4927906 + 843 WP_064143480.1 DUF4942 domain-containing protein -
IFX77_RS24065 4929999..4930289 - 291 WP_004153693.1 PerC family transcriptional regulator -
IFX77_RS24070 4930484..4930606 + 123 WP_004146686.1 hypothetical protein -
IFX77_RS24075 4930601..4931167 - 567 WP_002885396.1 LuxR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4910773..4931167 20394


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(19-117)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14037.93 Da        Isoelectric Point: 7.2922

>T173074 WP_064143481.1 NZ_CP061832:4926183-4926560 [Klebsiella pneumoniae]
MKTLPDTHEREASRCSSPVTIWQTLLARLLGQHYSLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
GTCAHSQLINSIDILRARRATGLLTRSNYRTVNDIIRGKDAEAKQ

Download         Length: 378 bp

>T173074 NZ_CP080091:3602800-3603057 [Salmonella enterica]
ATGAATGCCTCCGGCGTCAGCGTCCGCCACATCAACAGCAAAACCCACATGACCACCTATTACTCACAAATCCCCAGCCT
GCATCTTAAGGGCGACTGGCTGGAAGAAGCGGGATTTAAGACCGGGCGCGGCGTCACCGTGAAGATTTCACAGGGGTGTA
TTGTGCTGATGGCGGACAGTAACGAGGAGCAGAAGCTGCGCGAGCAGCTTTATCAGGCTAAACAGGTGGTTAAGGGAATT
AAGGACGTGCTGGTTTAG

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13751.48 Da        Isoelectric Point: 5.4906

>AT173074 WP_064143482.1 NZ_CP061832:4925759-4926136 [Klebsiella pneumoniae]
VSDTLPGTTLPDDNNDRTWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGQFSNADAYHLDQAFPLLLKQLELMLTSG
ELNPRHQHTVTLYARGLTCEADTLGSWGYVYMAVYPTPAAPATTA

Download         Length: 378 bp

>AT173074 NZ_CP080091:c3602975-3602643 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGATGCAGGCTGGGGATTTGTGAGTAATAGGTGGTCATGTGGGTTTTGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTATCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCC
GGGGCCGTATTTT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References