Detailed information of TA system TA173073

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 4769149..4769665
• Replicon: chromosome
• Accession: NZ_CP061832
• Organism: Klebsiella pneumoniae strain C0674

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IFX77_RS23275
• Protein ID: WP_023317444.1
• Coordinates: 4769149..4769433 (-)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: R4Y888
• Locus tag: IFX77_RS23280
• Protein ID: WP_002886901.1
• Coordinates: 4769423..4769665 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFX77_RS23250	4764544..4764852	-	309	WP_012737232.1	PTS sugar transporter subunit IIB	-
IFX77_RS23255	4764937..4765110	+	174	WP_032408826.1	hypothetical protein	-
IFX77_RS23260	4765113..4765856	+	744	WP_002886905.1	MurR/RpiR family transcriptional regulator	-
IFX77_RS23265	4766213..4768351	+	2139	WP_004186701.1	anaerobic ribonucleoside-triphosphate reductase	-
IFX77_RS23270	4768681..4769145	+	465	WP_004178375.1	anaerobic ribonucleoside-triphosphate reductase-activating protein	-
IFX77_RS23275	4769149..4769433	-	285	WP_023317444.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IFX77_RS23280	4769423..4769665	-	243	WP_002886901.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
IFX77_RS23285	4769743..4771653	-	1911	WP_004152270.1	BglG family transcription antiterminator	-
IFX77_RS23290	4771676..4772830	-	1155	WP_002886900.1	lactonase family protein	-
IFX77_RS23295	4772897..4773637	-	741	WP_004186692.1	KDGP aldolase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-80)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11151.99 Da
• Isoelectric Point: 10.3787

>T173073 WP_023317444.1 NZ_CP061832:c4769433-4769149 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESPRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Nucleotide

• Length: 285 bp

>T173073 NZ_CP080091:3412438-3412656 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9045.55 Da
• Isoelectric Point: 6.3340

>AT173073 WP_002886901.1 NZ_CP061832:c4769665-4769423 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Nucleotide

• Length: 243 bp

>AT173073 NZ_CP080091:3412036-3412410 [Salmonella enterica]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCCAATCCTGTTAGTTTGTCTTGTTAA

Structures

Antitoxin

• AlphaFold DB: A0A0H3GLP0