Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 4067832..4068451 Replicon chromosome
Accession NZ_CP061832
Organism Klebsiella pneumoniae strain C0674

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag IFX77_RS19945 Protein ID WP_002892050.1
Coordinates 4068233..4068451 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID J2DPF6
Locus tag IFX77_RS19940 Protein ID WP_002892066.1
Coordinates 4067832..4068206 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFX77_RS19930 4062984..4064177 + 1194 WP_002892072.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
IFX77_RS19935 4064200..4067346 + 3147 WP_020326861.1 multidrug efflux RND transporter permease subunit -
IFX77_RS19940 4067832..4068206 + 375 WP_002892066.1 Hha toxicity modulator TomB Antitoxin
IFX77_RS19945 4068233..4068451 + 219 WP_002892050.1 hemolysin expression modulator Hha Toxin
IFX77_RS19950 4068610..4069176 + 567 WP_002892030.1 maltose O-acetyltransferase -
IFX77_RS19955 4069148..4069288 - 141 WP_004147370.1 hypothetical protein -
IFX77_RS19960 4069309..4069779 + 471 WP_002892026.1 YlaC family protein -
IFX77_RS19965 4069754..4071205 - 1452 WP_002892023.1 PLP-dependent aminotransferase family protein -
IFX77_RS19970 4071306..4072004 + 699 WP_080899866.1 GNAT family N-acetyltransferase -
IFX77_RS19975 4072001..4072141 - 141 WP_002892018.1 type B 50S ribosomal protein L36 -
IFX77_RS19980 4072141..4072404 - 264 WP_002892011.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T173071 WP_002892050.1 NZ_CP061832:4068233-4068451 [Klebsiella pneumoniae]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

>T173071 NZ_CP080091:c2444889-2444734 [Salmonella enterica]
ATGAAGCAGCAAAAGGCGATGTTAATCGCCCTGATCGTCATCTGTTTAACCGTCATAGTGACGGCACTGGTAACGAGGAA
AGACCTCTGCGAGGTACGAATCCGAACCGGCCAGACGGAGGTCGCTGTCTTCACAGCTTACGAACCTGAGGAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14368.06 Da        Isoelectric Point: 4.8989

>AT173071 WP_002892066.1 NZ_CP061832:4067832-4068206 [Klebsiella pneumoniae]
MDEYSPKRHDIAQLRFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYAEDNKLIAQVDEYL
DDTFTLFSNYGINSTDLQKWKKSGNRLFRCFVNASRENPASLSC

Download         Length: 375 bp

>AT173071 NZ_CP080091:2444901-2444959 [Salmonella enterica]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGCAAAGCATGAAATTGGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GJ93

References