Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 814498..815155 Replicon chromosome
Accession NZ_CP061832
Organism Klebsiella pneumoniae strain C0674

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag IFX77_RS04040 Protein ID WP_002916310.1
Coordinates 814745..815155 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag IFX77_RS04035 Protein ID WP_002916312.1
Coordinates 814498..814764 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFX77_RS04010 809706..811139 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
IFX77_RS04015 811258..811986 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
IFX77_RS04020 812036..812347 + 312 WP_004144734.1 N(4)-acetylcytidine aminohydrolase -
IFX77_RS04025 812511..813170 + 660 WP_002916317.1 hemolysin III family protein -
IFX77_RS04030 813269..814252 - 984 WP_023286864.1 tRNA-modifying protein YgfZ -
IFX77_RS04035 814498..814764 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
IFX77_RS04040 814745..815155 + 411 WP_002916310.1 protein YgfX Toxin
IFX77_RS04045 815162..815683 - 522 WP_004144730.1 flavodoxin FldB -
IFX77_RS04050 815784..816680 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
IFX77_RS04055 816703..817416 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
IFX77_RS04060 817422..819155 + 1734 WP_004149758.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T173061 WP_002916310.1 NZ_CP061832:814745-815155 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

>T173061 NZ_CP080086:c29641-29360 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT173061 WP_002916312.1 NZ_CP061832:814498-814764 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT173061 NZ_CP080086:c29882-29631 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References