Detailed information of TA system TA173050

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /RES-TIGR02293
• Location: 125518..126419
• Replicon: plasmid pHSW1412-1
• Accession: NZ_CP061802
• Organism: Enterobacter mori strain HSW1412

Toxin (Protein)

• Gene name: -
• Uniprot ID: A0A837LJP8
• Locus tag: IDM36_RS23275
• Protein ID: WP_007372300.1
• Coordinates: 125518..125976 (-)
• Length: 153 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IDM36_RS23280
• Protein ID: WP_008786588.1
• Coordinates: 125973..126419 (-)
• Length: 149 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IDM36_RS23230	121244..121486	+	243	WP_007372291.1	hypothetical protein	-
IDM36_RS23235	121497..121895	+	399	WP_007372292.1	hypothetical protein	-
IDM36_RS23240	121979..122305	+	327	WP_007372293.1	hypothetical protein	-
IDM36_RS23245	122668..123006	-	339	WP_007372294.1	hypothetical protein	-
IDM36_RS23250	123244..123687	+	444	WP_007372295.1	hypothetical protein	-
IDM36_RS23255	123806..124147	+	342	WP_007372296.1	hypothetical protein	-
IDM36_RS23260	124306..124860	+	555	WP_007372297.1	hypothetical protein	-
IDM36_RS23265	124910..125176	+	267	WP_007372298.1	hypothetical protein	-
IDM36_RS23270	125244..125474	-	231	WP_007372299.1	hypothetical protein	-
IDM36_RS23275	125518..125976	-	459	WP_007372300.1	RES family NAD+ phosphorylase	Toxin
IDM36_RS23280	125973..126419	-	447	WP_008786588.1	DUF2384 domain-containing protein	Antitoxin
IDM36_RS23285	126568..126885	+	318	WP_007372302.1	hypothetical protein	-
IDM36_RS23290	126927..127769	+	843	WP_007372303.1	hypothetical protein	-
IDM36_RS23295	127741..128019	+	279	WP_007372304.1	hypothetical protein	-
IDM36_RS23300	128079..128522	+	444	WP_007372305.1	hypothetical protein	-
IDM36_RS23305	128809..128973	+	165	WP_007372306.1	hypothetical protein	-
IDM36_RS23310	129541..130383	+	843	WP_007372307.1	HNH endonuclease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	mcr-5.1 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / blaCTX-M-3 / blaTEM-1B	-	1..192279	192279

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (3-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (95-145)

Sequences

Toxin

Protein

• Length: 153 a.a.
• Molecular weight: 16975.40 Da
• Isoelectric Point: 4.5730

>T173050 WP_007372300.1 NZ_CP061802:c125976-125518 [Enterobacter mori]
VILYRLTKTRYLMTAWSGLGAKEAGGRWNSVGTAMVYLSETASLTMLETLVHIHAPQLLDDFTLLSLDVPDDQIQTFDMS
RLPDNWASEDAPAELALYGDNWAESGSSIALRIPSALSPVEFNYLLNPAHPELFDLMATVKKIPFRFDSRLK

Nucleotide

• Length: 459 bp

>T173050 NZ_CP080085:c2796800-2796693 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 149 a.a.
• Molecular weight: 16689.02 Da
• Isoelectric Point: 6.9812

>AT173050 WP_008786588.1 NZ_CP061802:c126419-125973 [Enterobacter mori]
MTMKVFSPDVTKTNQHCLWQVAGLDNDGIALMDKINHGLDGTVAKHISEWANITPSELRKMSGIPNTTFNRSIKDRFTAD
QSERLVRIIRVIERAVELFEGDKEAAHKWLNEANRGLSWKSPAELVSSETGALEVMRLITRIEHGVYS

Nucleotide

• Length: 447 bp

>AT173050 NZ_CP080085:2796857-2796912 [Escherichia coli]
TCAAGAATGGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTT

Structures

Toxin

• AlphaFold DB: A0A837LJP8