Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 118219..118769 Replicon plasmid pHSW1412-1
Accession NZ_CP061802
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name ccdB Uniprot ID S1EZ93
Locus tag IDM36_RS23205 Protein ID WP_007372286.1
Coordinates 118461..118769 (+) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID S1FMC3
Locus tag IDM36_RS23200 Protein ID WP_007372285.1
Coordinates 118219..118458 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS23170 113273..113977 - 705 WP_001067855.1 IS6-like element IS26 family transposase -
IDM36_RS23175 114183..114914 - 732 WP_002433159.1 IS21-like element helper ATPase IstB -
IDM36_RS23180 115236..115517 - 282 Protein_121 transposase -
IDM36_RS23185 115582..116289 + 708 WP_196391420.1 IS6 family transposase -
IDM36_RS23195 117874..118080 + 207 WP_007372284.1 hypothetical protein -
IDM36_RS23200 118219..118458 + 240 WP_007372285.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
IDM36_RS23205 118461..118769 + 309 WP_007372286.1 CcdB family protein Toxin
IDM36_RS23210 118790..118948 + 159 WP_016241558.1 hypothetical protein -
IDM36_RS23215 119103..119657 + 555 WP_007372288.1 hypothetical protein -
IDM36_RS23220 119727..120344 + 618 WP_007372289.1 hypothetical protein -
IDM36_RS23225 120427..120897 + 471 WP_007372290.1 hypothetical protein -
IDM36_RS23230 121244..121486 + 243 WP_007372291.1 hypothetical protein -
IDM36_RS23235 121497..121895 + 399 WP_007372292.1 hypothetical protein -
IDM36_RS23240 121979..122305 + 327 WP_007372293.1 hypothetical protein -
IDM36_RS23245 122668..123006 - 339 WP_007372294.1 hypothetical protein -
IDM36_RS23250 123244..123687 + 444 WP_007372295.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-5.1 / sul2 / aph(3'')-Ib / aph(6)-Id / qnrS1 / blaCTX-M-3 / blaTEM-1B - 1..192279 192279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(9-79)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11351.17 Da        Isoelectric Point: 8.5044

>T173049 WP_007372286.1 NZ_CP061802:118461-118769 [Enterobacter mori]
MQYTVYRNPGNSQAYPYLLDIQSDIIGELNTRLVIPLHRLKKGASAPVARLTPVIQVEGNDVILMTHEMASVRVKQLGQA
VMDASPFRHTIKSAVDFLLDGF

Download         Length: 309 bp

>T173049 NZ_CP080085:c2796317-2796210 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8784.97 Da        Isoelectric Point: 8.6387

>AT173049 WP_007372285.1 NZ_CP061802:118219-118458 [Enterobacter mori]
MQATAARQKKTVSVTLEPMLVQQAKDAGINLSATLAEALQSKLKASAAEEWKRQNRAGIQELNRITEEHGLLSDEYRTF

Download         Length: 240 bp

>AT173049 NZ_CP080085:2796365-2796431 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ93

Antitoxin

Source ID Structure
AlphaFold DB S1FMC3

References