Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 3986687..3987440 Replicon chromosome
Accession NZ_CP061801
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name yeeV Uniprot ID A0A097QYR4
Locus tag IDM36_RS19000 Protein ID WP_025799003.1
Coordinates 3986687..3987064 (-) Length 126 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID A0A7T0E0C6
Locus tag IDM36_RS19005 Protein ID WP_072269511.1
Coordinates 3987114..3987440 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS18970 3982285..3984132 + 1848 WP_182272681.1 RNA polymerase sigma factor RpoD -
IDM36_RS18975 3984230..3984736 - 507 WP_182918973.1 G/U mismatch-specific DNA glycosylase -
IDM36_RS18985 3985040..3985885 - 846 WP_025799009.1 DUF4942 domain-containing protein -
IDM36_RS18990 3985967..3986170 - 204 WP_025799007.1 DUF957 domain-containing protein -
IDM36_RS18995 3986199..3986690 - 492 WP_045888216.1 hypothetical protein -
IDM36_RS19000 3986687..3987064 - 378 WP_025799003.1 TA system toxin CbtA family protein Toxin
IDM36_RS19005 3987114..3987440 - 327 WP_072269511.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
IDM36_RS19010 3987497..3987718 - 222 WP_181498633.1 DUF987 domain-containing protein -
IDM36_RS19015 3987732..3988211 - 480 WP_025798999.1 DNA repair protein RadC -
IDM36_RS19020 3988223..3988654 - 432 WP_088903392.1 antirestriction protein -
IDM36_RS19025 3988877..3992032 - 3156 WP_077267777.1 AIDA repeat-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(4-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13993.97 Da        Isoelectric Point: 6.8515

>T173048 WP_025799003.1 NZ_CP061801:c3987064-3986687 [Enterobacter mori]
MQTQPVPPTQEASPRPSPVEIWLRLLSHLLDRHYGLTLNDTPFCNDGVIQEHIDAGISLCDAVNFIVEKYALIRTDRHGF
SAETQSPLISSIDILRARKACGLMARNGYRLVTDITTGKYSEVTR

Download         Length: 378 bp

>T173048 NZ_CP080085:c2327945-2327631 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12016.71 Da        Isoelectric Point: 6.4674

>AT173048 WP_072269511.1 NZ_CP061801:c3987440-3987114 [Enterobacter mori]
IAEPWWGLKRDITPCFGARLVQEGNRLHYLADRASITGQFSDADLRHLDQAFPLLLKQLELMLTSGELNPRHQHGVTLYA
KGLTCNADTLGSCGYVYIAIYPTPATTE

Download         Length: 327 bp

>AT173048 NZ_CP080085:c2327634-2327218 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A097QYR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7T0E0C6

References