Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 1761870..1762691 Replicon chromosome
Accession NZ_CP061801
Organism Enterobacter mori strain HSW1412

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag IDM36_RS08335 Protein ID WP_196391124.1
Coordinates 1762143..1762691 (+) Length 183 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID -
Locus tag IDM36_RS08330 Protein ID WP_182919747.1
Coordinates 1761870..1762139 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IDM36_RS08300 1757649..1758020 + 372 WP_182274464.1 helix-turn-helix transcriptional regulator -
IDM36_RS08305 1758094..1759335 + 1242 WP_182919746.1 bifunctional glucose-1-phosphatase/inositol phosphatase -
IDM36_RS08310 1759369..1759596 - 228 WP_166716999.1 YccJ family protein -
IDM36_RS08315 1759615..1760211 - 597 WP_182274466.1 NAD(P)H:quinone oxidoreductase -
IDM36_RS08320 1760604..1760774 + 171 WP_023332656.1 general stress protein -
IDM36_RS08325 1760891..1761796 + 906 WP_182274467.1 DMT family transporter -
IDM36_RS08330 1761870..1762139 + 270 WP_182919747.1 DUF1778 domain-containing protein Antitoxin
IDM36_RS08335 1762143..1762691 + 549 WP_196391124.1 GNAT family N-acetyltransferase Toxin
IDM36_RS08340 1762752..1763216 - 465 WP_196391125.1 SymE family type I addiction module toxin -
IDM36_RS08345 1763661..1765745 + 2085 WP_196391126.1 ATP-dependent endonuclease -
IDM36_RS08350 1765742..1767469 + 1728 Protein_1623 UvrD-helicase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(92-154)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 183 a.a.        Molecular weight: 20503.17 Da        Isoelectric Point: 6.4894

>T173035 WP_196391124.1 NZ_CP061801:1762143-1762691 [Enterobacter mori]
VANLTIDMFSEGTDYTFEDFDCGEPSLNSFLTEHLVRQHNGRILRGYLLKDRDHPRVLGYYTLSGSCFEKALLPSKTQQR
RIPYTNVPGVTLGRLAVHKELQGNEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNEQAKRFYLKQGFIPLSGENSNSLF
YPTKSIERLFEADEYSPPGEGL

Download         Length: 549 bp

>T173035 NZ_CP080082:c17118-16813 [Escherichia coli]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGTCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGCGCCCGCCTGCTGTCAGATAAAGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAAGAAGTG
GCCGATCTCAGCCACCGCGAAAATGACATCAAAAACGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10233.68 Da        Isoelectric Point: 5.8720

>AT173035 WP_182919747.1 NZ_CP061801:1761870-1762139 [Enterobacter mori]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAINNPPEPNERLKR
AAKRLQNME

Download         Length: 270 bp

>AT173035 NZ_CP080082:c17338-17120 [Escherichia coli]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGTCT
GGTAAGCACCACCATGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGAAAGCGGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References