Detailed information of TA system TA173033

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1142829..1143449
• Replicon: chromosome
• Accession: NZ_CP061801
• Organism: Enterobacter mori strain HSW1412

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: -
• Locus tag: IDM36_RS05330
• Protein ID: WP_181622491.1
• Coordinates: 1142829..1143047 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V3PBI9
• Locus tag: IDM36_RS05335
• Protein ID: WP_008499288.1
• Coordinates: 1143075..1143449 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IDM36_RS05300	1139134..1140699	-	1566	WP_182919505.1	EAL domain-containing protein	-
IDM36_RS05305	1140934..1141194	+	261	WP_182274631.1	type B 50S ribosomal protein L31	-
IDM36_RS05310	1141197..1141337	+	141	WP_003859006.1	type B 50S ribosomal protein L36	-
IDM36_RS05315	1141303..1141470	-	168	WP_196391418.1	hypothetical protein	-
IDM36_RS05320	1141482..1141949	-	468	WP_182273973.1	hypothetical protein	-
IDM36_RS05325	1142067..1142618	-	552	WP_182919506.1	maltose O-acetyltransferase	-
IDM36_RS05330	1142829..1143047	-	219	WP_181622491.1	hemolysin expression modulator Hha	Toxin
IDM36_RS05335	1143075..1143449	-	375	WP_008499288.1	Hha toxicity modulator TomB	Antitoxin
IDM36_RS05340	1143964..1147110	-	3147	WP_182273975.1	multidrug efflux RND transporter permease subunit AcrB	-
IDM36_RS05345	1147133..1148326	-	1194	WP_182273976.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-114)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8597.97 Da
• Isoelectric Point: 8.9008

>T173033 WP_181622491.1 NZ_CP061801:c1143047-1142829 [Enterobacter mori]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Nucleotide

• Length: 219 bp

>T173033 NZ_CP080080:c4113992-4113819 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14481.28 Da
• Isoelectric Point: 4.8886

>AT173033 WP_008499288.1 NZ_CP061801:c1143449-1143075 [Enterobacter mori]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Nucleotide

• Length: 375 bp

>AT173033 NZ_CP080080:c4114316-4114020 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: V3PBI9