Detailed information of TA system TA173031

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 342594..343347
• Replicon: chromosome
• Accession: NZ_CP061801
• Organism: Enterobacter mori strain HSW1412

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: R8WN26
• Locus tag: IDM36_RS01605
• Protein ID: WP_016154457.1
• Coordinates: 342594..342971 (-)
• Length: 126 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: -
• Locus tag: IDM36_RS01610
• Protein ID: WP_162838704.1
• Coordinates: 343021..343347 (-)
• Length: 109 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IDM36_RS01580	340108..340410	+	303	WP_182919281.1	adenylate cyclase	-
IDM36_RS01585	340699..340935	-	237	WP_016154458.1	hypothetical protein	-
IDM36_RS01590	340947..341792	-	846	Protein_303	DUF4942 domain-containing protein	-
IDM36_RS01595	341873..342076	-	204	WP_009652505.1	DUF957 domain-containing protein	-
IDM36_RS01600	342106..342597	-	492	WP_009652438.1	hypothetical protein	-
IDM36_RS01605	342594..342971	-	378	WP_016154457.1	TA system toxin CbtA family protein	Toxin
IDM36_RS01610	343021..343347	-	327	WP_162838704.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
IDM36_RS01615	343404..343625	-	222	WP_009652392.1	DUF987 domain-containing protein	-
IDM36_RS01620	343639..344121	-	483	WP_016154455.1	DNA repair protein RadC	-
IDM36_RS01625	344133..344351	-	219	WP_009652503.1	hypothetical protein	-
IDM36_RS01630	344362..344823	-	462	WP_045890390.1	antirestriction protein	-
IDM36_RS01635	344852..345106	-	255	WP_009652519.1	hypothetical protein	-
IDM36_RS01640	345106..345924	-	819	WP_009652424.1	DUF945 domain-containing protein	-
IDM36_RS01645	346028..346261	-	234	WP_009652474.1	DUF905 domain-containing protein	-
IDM36_RS01650	346317..346538	-	222	WP_009652443.1	hypothetical protein	-
IDM36_RS01655	346621..347133	-	513	WP_009652395.1	DUF4234 domain-containing protein	-
IDM36_RS01660	347182..347652	-	471	WP_009652431.1	hypothetical protein	-
IDM36_RS01665	347699..348010	-	312	WP_009652410.1	hypothetical protein	-
IDM36_RS01670	348023..348289	-	267	WP_009652486.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-112)

Antitoxin

• Antitoxin CbeA (4-103)

Sequences

Toxin

Protein

• Length: 126 a.a.
• Molecular weight: 14168.19 Da
• Isoelectric Point: 9.5224

>T173031 WP_016154457.1 NZ_CP061801:c342971-342594 [Enterobacter mori]
MQTQPVPPKREVSPRPSPVAIWQRLLSHLLDRHYGLTLNDTPFGKDGVIQEHIDAGISLCDAVNFIVEKYDLVRTDRRGF
NAETQSPLLTSIDILRARKATGLMTRHSYRAVTDITTGKYREVQP

Nucleotide

• Length: 378 bp

>T173031 NZ_CP080080:c3581481-3581083 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCGTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGTGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGTGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACAGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin

Protein

• Length: 109 a.a.
• Molecular weight: 12079.85 Da
• Isoelectric Point: 6.6283

>AT173031 WP_162838704.1 NZ_CP061801:c343347-343021 [Enterobacter mori]
IAAPWWGLKRDITPCFGARLVQEGNRLHYLNDRASITGTFSDADLRHLDQAFPLLLKQLELMLLSGELNPRHQHCVTLYA
KGLICEADSLGSHGYVYLAIYPTPATTE

Nucleotide

• Length: 327 bp

>AT173031 NZ_CP080080:c3581777-3581484 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATTACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGAGCT
GAAAAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Structures

Toxin

• AlphaFold DB: R8WN26