Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907-MazE
Location 7130857..7131440 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag dnm_RS27305 Protein ID WP_207680045.1
Coordinates 7131099..7131440 (+) Length 114 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag dnm_RS27300 Protein ID WP_207680044.1
Coordinates 7130857..7131099 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS27295 (dnm_089360) 7126765..7130676 + 3912 WP_207680043.1 helicase-related protein -
dnm_RS27300 (dnm_089370) 7130857..7131099 + 243 WP_207680044.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
dnm_RS27305 (dnm_089380) 7131099..7131440 + 342 WP_207680045.1 endoribonuclease MazF Toxin
dnm_RS27315 (dnm_089390) 7131931..7132128 - 198 WP_207680046.1 hypothetical protein -
dnm_RS27320 (dnm_089400) 7132125..7132916 - 792 WP_207680047.1 inositol monophosphatase family protein -
dnm_RS27325 (dnm_089420) 7133514..7134245 - 732 WP_207680048.1 amino acid ABC transporter ATP-binding protein -
dnm_RS27330 (dnm_089460) 7135229..7136131 - 903 WP_207680049.1 transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12365.49 Da        Isoelectric Point: 9.1932

>T173028 WP_207680045.1 NZ_CP061800:7131099-7131440 [Desulfonema magnum]
MNYVPDRGDVVWINMNPRAGHEQGGKRPALVLSPKAYNGKVRLALFCPITTRVKGYPFEVVIPEGCGVSGVILSDQIKSL
DWRARNADLACKLPDEVTTDVMKKLGTLLIGLT

Download         Length: 342 bp

>T173028 NZ_CP080080:2573940-2574047 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8680.78 Da        Isoelectric Point: 4.2259

>AT173028 WP_207680044.1 NZ_CP061800:7130857-7131099 [Desulfonema magnum]
MQTKIQKWGNSLALRIPKAFALNVNIEKETVVELSLDSGRIVITPVSAPGYTLEELLNGVSENSLHGETDTGDAVGEEVW

Download         Length: 243 bp

>AT173028 NZ_CP080080:c2573893-2573827 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References