Detailed information of TA system TA173024

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-YefM
• Location: 3066217..3066721
• Replicon: chromosome
• Accession: NZ_CP061800
• Organism: Desulfonema magnum strain 4be13

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: dnm_RS12145
• Protein ID: WP_207682915.1
• Coordinates: 3066467..3066721 (+)
• Length: 85 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: -
• Locus tag: dnm_RS12140
• Protein ID: WP_207682914.1
• Coordinates: 3066217..3066486 (+)
• Length: 90 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dnm_RS12135 (dnm_039500)	3061518..3066185	+	4668	WP_207682913.1	SPASM domain-containing protein	-
dnm_RS12140 (dnm_039510)	3066217..3066486	+	270	WP_207682914.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
dnm_RS12145 (dnm_039520)	3066467..3066721	+	255	WP_207682915.1	Txe/YoeB family addiction module toxin	Toxin
dnm_RS12150 (dnm_039530)	3066797..3067843	+	1047	WP_207682916.1	class I SAM-dependent methyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (1-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-74)

Sequences

Toxin

Protein

• Length: 85 a.a.
• Molecular weight: 10503.18 Da
• Isoelectric Point: 9.7311

>T173024 WP_207682915.1 NZ_CP061800:3066467-3066721 [Desulfonema magnum]
MMIAWTDRAWNEYLYWQKHDKKIVKRINELIRDIKRHPEEGIGKPEALRFDLSGKWSRRINQEHRLVYQVIDEMIVIFQC
RYHY

Nucleotide

• Length: 255 bp

>T173024 NZ_CP080080:972433-972768 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 90 a.a.
• Molecular weight: 10249.76 Da
• Isoelectric Point: 4.5858

>AT173024 WP_207682914.1 NZ_CP061800:3066217-3066486 [Desulfonema magnum]
MNAIAYSNFRKNFANIMEKICEDHDPVIITRKNLKPVVMMSLEDYNAIEETMYLLRSPANAAQLRASIAEFEAGNFNIRK
MIDNDDCMD

Nucleotide

• Length: 270 bp

>AT173024 NZ_CP080080:972185-972433 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA