Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 1996602..1997173 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag dnm_RS08055 Protein ID WP_207682160.1
Coordinates 1996602..1996925 (-) Length 108 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag dnm_RS08060 Protein ID WP_207682161.1
Coordinates 1996919..1997173 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS08050 (dnm_026040) 1994216..1995691 + 1476 WP_207679109.1 IS4 family transposase -
dnm_RS08055 (dnm_026070) 1996602..1996925 - 324 WP_207682160.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
dnm_RS08060 (dnm_026080) 1996919..1997173 - 255 WP_207682161.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
dnm_RS08065 (dnm_026090) 1997592..1997765 + 174 WP_207682162.1 hypothetical protein -
dnm_RS31190 (dnm_026100) 1997912..1998046 + 135 WP_276571864.1 hypothetical protein -
dnm_RS31195 (dnm_026110) 1998043..1998423 + 381 WP_207682163.1 DUF4263 domain-containing protein -
dnm_RS31200 (dnm_026120) 1998485..1998691 + 207 WP_207682164.1 DUF4263 domain-containing protein -
dnm_RS08080 (dnm_026140) 1999132..1999281 + 150 WP_207682165.1 hypothetical protein -
dnm_RS08085 (dnm_026150) 1999443..1999640 + 198 WP_207682166.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-105)

Antitoxin

SpoVT-AbrB domain

(7-46)


Sequences

Toxin        


Download         Length: 108 a.a.        Molecular weight: 12130.47 Da        Isoelectric Point: 10.4840

>T173022 WP_207682160.1 NZ_CP061800:c1996925-1996602 [Desulfonema magnum]
MVVSRFDVCLVNLDPTVGSEIKKVRPCLVISPDEMNHNIRTVIVAPMTTAGKNYPTRVQCMFKRKKGQIVLDQIRTVDKT
RVIKKLGVIDLKTQTEVISVLQQLFSF

Download         Length: 324 bp

>T173022 NZ_CP080080:737516-737812 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9567.69 Da        Isoelectric Point: 4.4843

>AT173022 WP_207682161.1 NZ_CP061800:c1997173-1996919 [Desulfonema magnum]
MRARIIKIGNSQGIRIPKPLLDQSGISTDVELEVEKHRIIIRPVPDVRAGWDNAFKQMAQNGDDSLESGADVISHSWDED
EWEW

Download         Length: 255 bp

>AT173022 NZ_CP080080:737814-738209 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References