Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1851325..1851902 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag dnm_RS07510 Protein ID WP_207682058.1
Coordinates 1851648..1851902 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag dnm_RS07505 Protein ID WP_207682057.1
Coordinates 1851325..1851651 (-) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS07495 (dnm_024340) 1846760..1848277 + 1518 WP_207682055.1 FG-GAP-like repeat-containing protein -
dnm_RS07500 (dnm_024350) 1848328..1850757 + 2430 WP_207682056.1 cohesin domain-containing protein -
dnm_RS07505 (dnm_024390) 1851325..1851651 - 327 WP_207682057.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
dnm_RS07510 (dnm_024400) 1851648..1851902 - 255 WP_207682058.1 type II toxin-antitoxin system HicA family toxin Toxin
dnm_RS07515 (dnm_024420) 1852078..1852734 - 657 WP_207682059.1 Uma2 family endonuclease -
dnm_RS07520 (dnm_024440) 1852894..1854063 - 1170 WP_207682061.1 putative DNA binding domain-containing protein -
dnm_RS07525 (dnm_024460) 1854593..1855363 + 771 WP_207682062.1 hypothetical protein -
dnm_RS07530 (dnm_024470) 1855409..1855750 + 342 WP_207682063.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-82)

Antitoxin

Uncharacterised protein family HicB

(51-99)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9670.21 Da        Isoelectric Point: 11.2602

>T173021 WP_207682058.1 NZ_CP061800:c1851902-1851648 [Desulfonema magnum]
MNKKQRRTLEKIFDNPVQSNIEWNDIEKMLIALGAEISEGRGSRIRIALNNVRAVFHRPHPRKETDKGAVVSMRRFLTEA
GITL

Download         Length: 255 bp

>T173021 NZ_CP080080:688545-688928 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCACGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTTACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTTGAAAAATACGCACTGGTACGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATTCTCCGGGCTCGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCAGGAGTCGAAACGATGCAACTGA

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12473.92 Da        Isoelectric Point: 4.2692

>AT173021 WP_207682057.1 NZ_CP061800:c1851651-1851325 [Desulfonema magnum]
MKYKEYIAKVEYDDEADIFHGDVINIRDVITFQGKSVEELKEAFIDSVEDYIEFCSERGEEPDKPFSGSFTINLPPDLHK
KIVLAIEKSDKNLDNWVKDVFENAVSSH

Download         Length: 327 bp

>AT173021 NZ_CP080080:688087-688455 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACGCATCCCGATGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGTACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTACAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGTTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References