Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1833246..1833871 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag dnm_RS07430 Protein ID WP_207682043.1
Coordinates 1833476..1833871 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag dnm_RS07425 Protein ID WP_207682042.1
Coordinates 1833246..1833476 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS07405 (dnm_024020) 1828453..1829658 + 1206 WP_207682039.1 tryptophan synthase subunit beta -
dnm_RS07410 (dnm_024040) 1829768..1830568 + 801 WP_207682040.1 tryptophan synthase subunit alpha -
dnm_RS07415 (dnm_024060) 1831157..1832107 + 951 Protein_1459 methyl-accepting chemotaxis protein -
dnm_RS07425 (dnm_024090) 1833246..1833476 + 231 WP_207682042.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
dnm_RS07430 (dnm_024100) 1833476..1833871 + 396 WP_207682043.1 type II toxin-antitoxin system VapC family toxin Toxin
dnm_RS07435 (dnm_024130) 1834441..1834647 + 207 WP_207682044.1 zinc ribbon domain-containing protein -
dnm_RS07440 (dnm_024160) 1835155..1835613 + 459 WP_207682045.1 ribose 5-phosphate isomerase B -
dnm_RS07445 (dnm_024180) 1835716..1836951 + 1236 WP_207683620.1 serine hydroxymethyltransferase -
dnm_RS07450 (dnm_024220) 1837743..1838198 + 456 WP_207682046.1 transcriptional regulator NrdR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14815.23 Da        Isoelectric Point: 5.2064

>T173020 WP_207682043.1 NZ_CP061800:1833476-1833871 [Desulfonema magnum]
MYLLDTNICIYIINKKPASVVEKIKTLNPNDIKLSSISVGELEYGVSKSTNREKNRNALVEFVSCFDILSFNDSDAEVFG
MIRAYLEKKGTVIGPYDMQIAAQAISCKLTLITNNTKEFIRIPELMLDNWI

Download         Length: 396 bp

>T173020 NZ_CP080080:625232-625546 [Escherichia coli]
ATGCACCTGATAACTCAAAAAGCATTGAAAGATGCTGCGGAAAAATACCCGCAACATAAAACGGAGTTGGTGGCTCTGGG
GAACACGATTGCTAAGGGATATTTCAAAAAACCTGAGTCATTAAAAGCAGTATTCCCATCTCTGGATAACTTCAAATATC
TGGATAAGCATTATGTTTTCAATGTTGGGGGCAATGAATTACGTGTTGTAGCAATGGTCTTTTTTGAATCGCAAAAGTGC
TACATACGTGAAGTTATGACGCATAAAGAATACGATTTCTTTACCGCTGTTCATCGTACTAAGGGGAAAAAATGA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8805.96 Da        Isoelectric Point: 4.7344

>AT173020 WP_207682042.1 NZ_CP061800:1833246-1833476 [Desulfonema magnum]
MLSSKVFISGNSQAVRLPKEYQVSEKELFIQKIGNTIILFPKSNPWEAFEHSLNEFTEDFMQEGRNQPAMQERDGL

Download         Length: 231 bp

>AT173020 NZ_CP080080:625543-625959 [Escherichia coli]
ATGATTGCGATTGCCGACATCTTGCAAGCAGGAGAAAAGCTAACTGCTGTGGCACCTTTTCTGGCGGGTATTCAGAACGA
GGAACAATACACCCAGGCGCTGGAACTGGTAGATCATCTGCTGCTCAACGATCCTGAAAACCCCTTGCTGGATCTGGTGT
GTGCCAAAATAACCGCGTGGGAAGAATCAGCGCCCGAATTTGCGGAATTTAATGCCATGGCTCAAGCCATGCCTGGCGGT
ATAGCCGTGATTCGTACCCTTATGGATCAATATGGTTTAACCCTTTCCGATCTGCCGGAAATTGGCAGTAAATCTATGGT
GTCACGCGTTTTGAGCGGGAAGAGGAAATTAACGCTGGAACACGCTAAAAAATTGGCAACGCGATTCGGCATTTCTCCCG
CCTTGTTTATTGATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References