Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 321683..323157 Replicon chromosome
Accession NZ_CP061800
Organism Desulfonema magnum strain 4be13

Toxin (Protein)


Gene name HipA1 Uniprot ID -
Locus tag dnm_RS01255 Protein ID WP_207680911.1
Coordinates 321922..323157 (+) Length 412 a.a.

Antitoxin (Protein)


Gene name HipB1 Uniprot ID -
Locus tag dnm_RS01250 Protein ID WP_219739698.1
Coordinates 321683..321925 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnm_RS01230 (dnm_004080) 318374..318640 + 267 WP_207680907.1 alpha/beta hydrolase -
dnm_RS01235 (dnm_004090) 318691..318855 + 165 WP_207680908.1 hypothetical protein -
dnm_RS01240 (dnm_004110) 319421..320146 + 726 WP_207680909.1 CoA pyrophosphatase -
dnm_RS01245 (dnm_004120) 320148..321044 + 897 WP_207680910.1 metallophosphoesterase -
dnm_RS01250 (dnm_004150) 321683..321925 + 243 WP_219739698.1 helix-turn-helix transcriptional regulator Antitoxin
dnm_RS01255 (dnm_004160) 321922..323157 + 1236 WP_207680911.1 type II toxin-antitoxin system HipA family toxin Toxin
dnm_RS01260 (dnm_004170) 323202..323438 - 237 WP_207680912.1 hypothetical protein -
dnm_RS01265 (dnm_004180) 323591..324196 - 606 WP_207680913.1 DUF4384 domain-containing protein -
dnm_RS01270 (dnm_004190) 324324..325634 - 1311 WP_207680914.1 hypothetical protein -
dnm_RS01275 (dnm_004200) 325709..326284 - 576 WP_207680915.1 hypothetical protein -
dnm_RS01280 (dnm_004210) 326277..326924 - 648 WP_207680916.1 hypothetical protein -
dnm_RS01285 327501..327818 + 318 WP_207680917.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(18-73)


Sequences

Toxin        


Download         Length: 412 a.a.        Molecular weight: 46799.87 Da        Isoelectric Point: 9.0996

>T173019 WP_207680911.1 NZ_CP061800:321922-323157 [Desulfonema magnum]
MKTLRVFLNDRPVGELRSDKKRRLVFQYHREYLGASDAHPLSLSLPLGELPFEEDIARPFFSNLLPEGDIRTIIARFVRV
SGKNDMALLEKIGGECAGAVSVLPEGFVPEKKGGYIRLSRDELDSMMAADTGRPLLINREELRLSLAGAQDKLPVFIKDG
EYFLPTGNMPSSHIIKPRNRYFGGTVQNEAFCMKLAKAAGLPVPGSHIWKGEKNIAYVVERYDRARDAEGNISRIHQEDF
CQAMGYLPDQKYESEGGPGLAECFSLLEKFSAQPIRDRKNFISWVIFNFLIGNADAHAKNISLLFRHGKIYLAPFYDLMS
TLVYPELSQKMSMKIGKENRYKWTRKRHWERFARGIGMKPRFVFSIAEDMAERLKTESADIAGAFASWYAEKELIEKIGN
IIEKHTSSFEW

Download         Length: 1236 bp

>T173019 NZ_CP080080:177847-177954 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9079.62 Da        Isoelectric Point: 9.5743

>AT173019 WP_219739698.1 NZ_CP061800:321683-321925 [Desulfonema magnum]
MKKIFPNGNIMNDIKEIGYIIRKKRREYGLTQVEAAGLCNVGVRFMSELENGKPTLQVGKVLHVLEAYGFSVTITHREDL

Download         Length: 243 bp

>AT173019 NZ_CP080080:c177799-177733 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References