Detailed information of TA system TA173017

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 6342790..6343409
• Replicon: chromosome
• Accession: NZ_CP061799
• Organism: Desulfonema limicola strain 5ac10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: dnl_RS27165
• Protein ID: WP_207689353.1
• Coordinates: 6343023..6343409 (+)
• Length: 129 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: dnl_RS27160
• Protein ID: WP_207689352.1
• Coordinates: 6342790..6343026 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dnl_RS27145 (dnl_59250)	6338688..6340277	-	1590	WP_207687548.1	hypothetical protein	-
dnl_RS27150	6340396..6341274	+	879	WP_207689350.1	right-handed parallel beta-helix repeat-containing protein	-
dnl_RS27155 (dnl_59280)	6341716..6342054	+	339	WP_207689351.1	hypothetical protein	-
dnl_RS27160 (dnl_59320)	6342790..6343026	+	237	WP_207689352.1	hypothetical protein	Antitoxin
dnl_RS27165 (dnl_59330)	6343023..6343409	+	387	WP_207689353.1	type II toxin-antitoxin system VapC family toxin	Toxin
dnl_RS27170 (dnl_59340)	6343614..6343793	+	180	WP_207689354.1	hypothetical protein	-
dnl_RS27175 (dnl_59350)	6343908..6345419	-	1512	WP_207687161.1	ISKra4 family transposase	-
dnl_RS27180 (dnl_59360)	6345670..6347136	-	1467	WP_207689355.1	HAMP domain-containing methyl-accepting chemotaxis protein	-
dnl_RS27185 (dnl_59370)	6347173..6347658	-	486	WP_207689356.1	cytochrome c family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 129 a.a.
• Molecular weight: 14691.18 Da
• Isoelectric Point: 7.9239

>T173017 WP_207689353.1 NZ_CP061799:6343023-6343409 [Desulfonema limicola]
MKLLLDTHVFLWYISKDSRLPNAMLENIRNPDNEVFLSVVSVWETIIKYQIGKLPLPQSPEIYLPTQRKRHSISSLILDE
SSVCHLSKLPSIHRDPFDRILICQAIEHGLTIATIDNAIKSYAVNILK

Nucleotide

• Length: 387 bp

>T173017 NZ_CP080076:143509-143658 [Escherichia coli]
ATGACGAAATATGCCCTTATCGGGTTGCTCGCCGTGTGCGCCACTGTGTTGTGTTTTTCACTGATATTCAGGGAACGGTT
ATGTGAGCTGAATATTCACAGAGGAAATACAGTGGTGCAGGTAACTCTGGCCTACGAAGCACGGAAGTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8899.13 Da
• Isoelectric Point: 3.7080

>AT173017 WP_207689352.1 NZ_CP061799:6342790-6343026 [Desulfonema limicola]
MISVTIDDIQQDLLYYLKQINFGETVIILQADKPIAELKPISDSKILRPFGLCEGEFTVPDDFDEPLPENIIQEFEGQ

Nucleotide

• Length: 237 bp

>AT173017 NZ_CP080076:c143465-143404 [Escherichia coli]
TTAAGGTACTTCATGCAGACCTCACGAGTTAATGGATTAACGAGTGGGGTCTTCGCATTTCT