Detailed information of TA system TA173016

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/LOTUS_5_Limkain_b1-Phd
• Location: 5236367..5237040
• Replicon: chromosome
• Accession: NZ_CP061799
• Organism: Desulfonema limicola strain 5ac10

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: dnl_RS22220
• Protein ID: WP_207688407.1
• Coordinates: 5236367..5236792 (-)
• Length: 142 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: dnl_RS22225
• Protein ID: WP_207688408.1
• Coordinates: 5236789..5237040 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
dnl_RS22200 (dnl_48560)	5231394..5232923	+	1530	WP_207688404.1	BCCT family transporter	-
dnl_RS22205 (dnl_48570)	5233370..5234587	-	1218	WP_207688405.1	aspartate kinase	-
dnl_RS22210 (dnl_48580)	5234587..5235087	-	501	WP_207688406.1	tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE	-
dnl_RS22215 (dnl_48590)	5235088..5236155	-	1068	WP_207692639.1	RIP metalloprotease RseP	-
dnl_RS22220 (dnl_48600)	5236367..5236792	-	426	WP_207688407.1	type II toxin-antitoxin system VapC family toxin	Toxin
dnl_RS22225 (dnl_48610)	5236789..5237040	-	252	WP_207688408.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
dnl_RS22230 (dnl_48620)	5237249..5237683	-	435	WP_207688409.1	type II toxin-antitoxin system VapC family toxin	-
dnl_RS22235 (dnl_48630)	5237680..5237907	-	228	WP_207688410.1	hypothetical protein	-
dnl_RS22240 (dnl_48650)	5237990..5238283	-	294	WP_207688411.1	hypothetical protein	-
dnl_RS22245 (dnl_48660)	5238289..5238558	-	270	WP_207688412.1	hypothetical protein	-
dnl_RS22250 (dnl_48670)	5239147..5239386	-	240	WP_207687358.1	hypothetical protein	-
dnl_RS22255 (dnl_48680)	5239373..5239615	-	243	WP_207687499.1	hypothetical protein	-
dnl_RS22260 (dnl_48690)	5239993..5241144	+	1152	WP_207688413.1	hypothetical protein	-
dnl_RS22265	5241657..5241887	-	231	WP_207688414.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-70)

Sequences

Toxin

Protein

• Length: 142 a.a.
• Molecular weight: 15808.13 Da
• Isoelectric Point: 6.9778

>T173016 WP_207688407.1 NZ_CP061799:c5236792-5236367 [Desulfonema limicola]
MNYLLDTCVISELVKPTPNEAVINWMNHTPNERLFLSVIIIGEIRKGITKLPESKKKSQLTNWLNTLLEDYQARIYPINI
TVAENWGIIQGKAENNGTPVASVNSLIAAVAQTYNLIVVTRNENDFASTNVTILNPWKNQG

Nucleotide

• Length: 426 bp

>T173016 NZ_CP080075:c4523579-4523268 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9685.21 Da
• Isoelectric Point: 9.5841

>AT173016 WP_207688408.1 NZ_CP061799:c5237040-5236789 [Desulfonema limicola]
MNTSWKLQDAKAKFSQVVENALKTGPQYVTRRGQEAVVILSVKEYKKITTKKPTLKEFLLNCPKMDDGFEFERQKDCPRD
IEF

Nucleotide

• Length: 252 bp

>AT173016 NZ_CP080075:c4523267-4522977 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG