Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF-MazE
Location 2084618..2085195 Replicon chromosome
Accession NZ_CP061799
Organism Desulfonema limicola strain 5ac10

Toxin (Protein)


Gene name mazE Uniprot ID -
Locus tag dnl_RS09025 Protein ID WP_207691403.1
Coordinates 2084618..2084947 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazF Uniprot ID -
Locus tag dnl_RS09030 Protein ID WP_207691404.1
Coordinates 2084941..2085195 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
dnl_RS08990 (dnl_19480) 2080293..2080898 - 606 WP_207691396.1 FmdE family protein -
dnl_RS08995 (dnl_19490) 2080929..2081636 - 708 WP_207691397.1 cytochrome c biogenesis protein CcdA -
dnl_RS09000 (dnl_19500) 2081645..2082019 - 375 WP_207691398.1 thioredoxin family protein -
dnl_RS09005 (dnl_19510) 2082135..2082545 - 411 WP_207691399.1 hypothetical protein -
dnl_RS09010 (dnl_19520) 2082558..2083082 - 525 WP_207691400.1 (Fe-S)-binding protein -
dnl_RS09015 (dnl_19530) 2083098..2083991 - 894 WP_207691401.1 sulfite exporter TauE/SafE family protein -
dnl_RS09020 (dnl_19540) 2084142..2084474 - 333 Protein_1774 metalloregulator ArsR/SmtB family transcription factor -
dnl_RS09025 (dnl_19550) 2084618..2084947 - 330 WP_207691403.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
dnl_RS09030 (dnl_19560) 2084941..2085195 - 255 WP_207691404.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
dnl_RS09035 (dnl_19570) 2085289..2087952 - 2664 WP_207691405.1 TaqI-like C-terminal specificity domain-containing protein -
dnl_RS09040 (dnl_19580) 2087958..2088761 - 804 WP_207691406.1 type I restriction enzyme HsdR N-terminal domain-containing protein -
dnl_RS09045 (dnl_19590) 2089140..2089802 + 663 WP_207691407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-107)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12499.78 Da        Isoelectric Point: 10.2977

>T173011 WP_207691403.1 NZ_CP061799:c2084947-2084618 [Desulfonema limicola]
MVKKDVHRFEIWLVQLDPAQGSEIKKTRPCVVVSPDEMAALRTVIVAPMTSKGFHYPTRIQYTFQGKKGLILLDQLRTVD
KSRLLQRVGLISQNSQIKIINCLQELFAY

Download         Length: 330 bp

>T173011 NZ_CP080075:3425180-3425398 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTATACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9937.26 Da        Isoelectric Point: 4.4189

>AT173011 WP_207691404.1 NZ_CP061799:c2085195-2084941 [Desulfonema limicola]
MTTLIRIGNSQGIRIPKTVIEQAQLKDKQLEFKIIDEGLLIQPVKKNREGWKEQFDKTLKSQDLNESDQEWLNAPLVDEE
DWEW

Download         Length: 255 bp

>AT173011 NZ_CP080075:3424780-3425154 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTTAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References