Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 2717705..2718210 Replicon chromosome
Accession NZ_CP061780
Organism Pseudomonas aeruginosa strain ZBX-P11

Toxin (Protein)


Gene name parE Uniprot ID V6A7K8
Locus tag IFJ77_RS12645 Protein ID WP_003083773.1
Coordinates 2717705..2717986 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag IFJ77_RS12650 Protein ID WP_003083775.1
Coordinates 2717983..2718210 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ77_RS12620 (IFJ77_12620) 2712956..2714305 + 1350 WP_003119513.1 C4-dicarboxylate transporter DctA -
IFJ77_RS12625 (IFJ77_12625) 2714354..2715040 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IFJ77_RS12630 (IFJ77_12630) 2715141..2715875 + 735 WP_003110658.1 GntR family transcriptional regulator -
IFJ77_RS12635 (IFJ77_12635) 2716055..2716465 + 411 WP_003110659.1 aegerolysin family protein -
IFJ77_RS12640 (IFJ77_12640) 2716497..2717405 - 909 WP_003083769.1 LysR family transcriptional regulator -
IFJ77_RS12645 (IFJ77_12645) 2717705..2717986 - 282 WP_003083773.1 type II toxin-antitoxin system toxin ParE Toxin
IFJ77_RS12650 (IFJ77_12650) 2717983..2718210 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
IFJ77_RS12655 (IFJ77_12655) 2718386..2719006 - 621 WP_003101226.1 hypothetical protein -
IFJ77_RS12660 (IFJ77_12660) 2719107..2719607 + 501 WP_003162763.1 LEA type 2 family protein -
IFJ77_RS12665 (IFJ77_12665) 2719680..2720021 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
IFJ77_RS12670 (IFJ77_12670) 2720104..2721531 - 1428 WP_003083784.1 GABA permease -
IFJ77_RS12675 (IFJ77_12675) 2721700..2723193 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10462.19 Da        Isoelectric Point: 10.0435

>T173003 WP_003083773.1 NZ_CP061780:c2717986-2717705 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLTLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T173003 NZ_CP080075:1780463-1780717 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATATCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT173003 WP_003083775.1 NZ_CP061780:c2718210-2717983 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT173003 NZ_CP080075:1780215-1780466 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6XRW

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References