Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /Xre(antitoxin)
Location 553039..554297 Replicon chromosome
Accession NZ_CP061780
Organism Pseudomonas aeruginosa strain ZBX-P11

Toxin (Protein)


Gene name - Uniprot ID A0A509JCW5
Locus tag IFJ77_RS02605 Protein ID WP_021264413.1
Coordinates 553039..553794 (-) Length 252 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID V6AJU7
Locus tag IFJ77_RS02610 Protein ID WP_003086329.1
Coordinates 553929..554297 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ77_RS02595 (IFJ77_02595) 548210..550753 + 2544 WP_023101446.1 acyl-homoserine-lactone acylase QuiP -
IFJ77_RS02600 (IFJ77_02600) 550908..552269 - 1362 WP_073647918.1 DNA recombination protein RmuC -
IFJ77_RS02605 (IFJ77_02605) 553039..553794 - 756 WP_021264413.1 RES family NAD+ phosphorylase Toxin
IFJ77_RS02610 (IFJ77_02610) 553929..554297 - 369 WP_003086329.1 DUF2384 domain-containing protein Antitoxin
IFJ77_RS02615 (IFJ77_02615) 554370..555656 - 1287 WP_003086327.1 FAD-binding oxidoreductase -
IFJ77_RS02620 (IFJ77_02620) 555712..557205 - 1494 WP_003086325.1 aldehyde dehydrogenase family protein -
IFJ77_RS02625 (IFJ77_02625) 557380..557856 + 477 WP_019486191.1 elongation factor GreAB -
IFJ77_RS02630 (IFJ77_02630) 557859..558134 - 276 WP_023088486.1 zinc ribbon domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(63-207)

Antitoxin

Cro/C1-type helix-turn-helix domain

(23-47)


Sequences

Toxin        


Download         Length: 252 a.a.        Molecular weight: 28217.33 Da        Isoelectric Point: 8.0554

>T173000 WP_021264413.1 NZ_CP061780:c553794-553039 [Pseudomonas aeruginosa]
VSEIWRQCKGERHVRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLQTAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAIRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Download         Length: 756 bp

>T173000 NZ_CP080075:1003416-1003751 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTATACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13367.63 Da        Isoelectric Point: 9.9874

>AT173000 WP_003086329.1 NZ_CP061780:c554297-553929 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Download         Length: 369 bp

>AT173000 NZ_CP080075:1003168-1003416 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A509JCW5

Antitoxin

Source ID Structure
AlphaFold DB V6AJU7

References