Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/-
Location 2876437..2877658 Replicon chromosome
Accession NZ_CP061779
Organism Pseudomonas aeruginosa strain ZBX-P12

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag IFJ78_RS13230 Protein ID WP_003114949.1
Coordinates 2877080..2877658 (+) Length 193 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag IFJ78_RS13225 Protein ID WP_019371885.1
Coordinates 2876437..2876991 (+) Length 185 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ78_RS13200 (IFJ78_13195) 2872005..2872556 + 552 WP_003102727.1 XRE family transcriptional regulator -
IFJ78_RS13205 (IFJ78_13200) 2872553..2872951 - 399 WP_003088123.1 NADH-quinone oxidoreductase subunit A -
IFJ78_RS13210 (IFJ78_13205) 2872964..2873287 - 324 WP_003102734.1 multidrug efflux SMR transporter -
IFJ78_RS13215 (IFJ78_13210) 2873618..2874079 + 462 WP_003102736.1 (2Fe-2S)-binding protein -
IFJ78_RS13220 (IFJ78_13215) 2874084..2876279 + 2196 WP_003122807.1 xanthine dehydrogenase family protein molybdopterin-binding subunit -
IFJ78_RS13225 (IFJ78_13220) 2876437..2876991 + 555 WP_019371885.1 helix-turn-helix transcriptional regulator Antitoxin
IFJ78_RS13230 (IFJ78_13225) 2877080..2877658 + 579 WP_003114949.1 HD domain-containing protein Toxin
IFJ78_RS13235 (IFJ78_13230) 2877766..2878953 - 1188 WP_003102741.1 HlyD family efflux transporter periplasmic adaptor subunit -
IFJ78_RS13240 (IFJ78_13235) 2878943..2881114 - 2172 WP_003114950.1 type I secretion system permease/ATPase -
IFJ78_RS13245 (IFJ78_13240) 2881104..2882381 - 1278 WP_003102743.1 TolC family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HD domain

(16-170)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-62)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 21897.75 Da        Isoelectric Point: 5.3655

>T172996 WP_003114949.1 NZ_CP061779:2877080-2877658 [Pseudomonas aeruginosa]
MSLELLSNRLEFLREAERLKDVLRSAHTSSGRPESTAEHSWRLCLMALAFEDQLAGLDLGKVLRMCVVHDLGEAIHGDIP
AVEQAAHPDKGEQERADLLQLTRHLDAPLRDRLLALWDEYERGESAEALAVKALDKLETLLQHTQGDNPADFDYAFNLDY
GRRYTDRAPLFKTLRELLDARTRQRLAVRRDA

Download         Length: 579 bp

>T172996 NZ_CP080071:c10177-9896 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin


Download         Length: 185 a.a.        Molecular weight: 20440.60 Da        Isoelectric Point: 8.1590

>AT172996 WP_019371885.1 NZ_CP061779:2876437-2876991 [Pseudomonas aeruginosa]
MTEPLPSSSLGPALRRWRLLHRVKQTHAAELLGVAQSTISRWESGTQALLVEERARLERLLGARLEAAADQALARLVEAN
PQPVHLICDLTHRLLACSPARAAQFGVPLGELLDRSLWPYCSEEILRQEATLDELGWRELLAPPALEFASGANASAIVPI
RRSRCRWTRMTLSDGRAVRLVETL

Download         Length: 555 bp

>AT172996 NZ_CP080071:c10418-10167 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References