Detailed information of TA system TA172995

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 1593874..1594390
• Replicon: chromosome
• Accession: NZ_CP061779
• Organism: Pseudomonas aeruginosa strain ZBX-P12

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IFJ78_RS07650
• Protein ID: WP_071557699.1
• Coordinates: 1594109..1594390 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: IFJ78_RS07645
• Protein ID: WP_033942931.1
• Coordinates: 1593874..1594119 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ78_RS07630 (IFJ78_07625)	1589600..1592767	+	3168	WP_033942936.1	helicase-related protein	-
IFJ78_RS07635 (IFJ78_07630)	1592891..1593349	+	459	Protein_1511	hypothetical protein	-
IFJ78_RS07640 (IFJ78_07635)	1593267..1593692	-	426	WP_227495363.1	hypothetical protein	-
IFJ78_RS07645 (IFJ78_07640)	1593874..1594119	+	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IFJ78_RS07650 (IFJ78_07645)	1594109..1594390	+	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IFJ78_RS07655 (IFJ78_07650)	1594644..1595141	-	498	WP_033942928.1	DNA repair protein RadC	-
IFJ78_RS07660 (IFJ78_07655)	1595152..1596063	-	912	WP_033942927.1	hypothetical protein	-
IFJ78_RS07665 (IFJ78_07660)	1596156..1597160	-	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
IFJ78_RS07670 (IFJ78_07665)	1597235..1598203	-	969	WP_033942925.1	DUF932 domain-containing protein	-
IFJ78_RS33140	1598263..1598595	-	333	WP_071557700.1	hypothetical protein	-
IFJ78_RS07675 (IFJ78_07670)	1599030..1599227	+	198	WP_232092115.1	AlpA family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T172995 WP_071557699.1 NZ_CP061779:1594109-1594390 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T172995 NZ_CP080070:c4197343-4197170 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT172995 WP_033942931.1 NZ_CP061779:1593874-1594119 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT172995 NZ_CP080070:c4197667-4197371 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGATT
AAGATCATTGATGTATGATATGAATTTCTCTTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAATT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2