Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | PfiT-PfiA/ParE(toxin) |
Location | 6688772..6689380 | Replicon | chromosome |
Accession | NZ_CP061778 | ||
Organism | Pseudomonas aeruginosa strain ZBX-P13 |
Toxin (Protein)
Gene name | PfiT | Uniprot ID | A0A444LUU5 |
Locus tag | IFJ79_RS30955 | Protein ID | WP_019486378.1 |
Coordinates | 6688772..6689119 (-) | Length | 116 a.a. |
Antitoxin (Protein)
Gene name | PfiA | Uniprot ID | A0A0B0C355 |
Locus tag | IFJ79_RS30960 | Protein ID | WP_003114155.1 |
Coordinates | 6689129..6689380 (-) | Length | 84 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
IFJ79_RS30925 (IFJ79_30930) | 6684191..6684403 | + | 213 | WP_003085460.1 | cysteine-rich CWC family protein | - |
IFJ79_RS30930 (IFJ79_30935) | 6684403..6685095 | + | 693 | WP_003085458.1 | 16S rRNA pseudouridine(516) synthase | - |
IFJ79_RS30935 (IFJ79_30940) | 6685231..6686274 | + | 1044 | WP_003134392.1 | L,D-transpeptidase | - |
IFJ79_RS30940 (IFJ79_30945) | 6686354..6687091 | + | 738 | WP_003085453.1 | murein L,D-transpeptidase catalytic domain family protein | - |
IFJ79_RS30945 (IFJ79_30950) | 6687543..6688445 | + | 903 | WP_003085447.1 | (R)-3-hydroxydecanoyl-ACP:CoA transacylase | - |
IFJ79_RS30955 (IFJ79_30960) | 6688772..6689119 | - | 348 | WP_019486378.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
IFJ79_RS30960 (IFJ79_30965) | 6689129..6689380 | - | 252 | WP_003114155.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
IFJ79_RS30965 (IFJ79_30970) | 6689594..6690577 | - | 984 | WP_033990852.1 | tyrosine-type recombinase/integrase | - |
IFJ79_RS30970 (IFJ79_30975) | 6690577..6691869 | - | 1293 | WP_033990854.1 | hypothetical protein | - |
IFJ79_RS30975 (IFJ79_30980) | 6692099..6693373 | - | 1275 | WP_033990855.1 | zonular occludens toxin family protein | - |
IFJ79_RS30980 (IFJ79_30985) | 6693377..6693733 | - | 357 | WP_003114150.1 | DUF2523 family protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Prophage | catB7 | - | 6688772..6711864 | 23092 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 116 a.a. Molecular weight: 12956.72 Da Isoelectric Point: 4.4212
>T172991 WP_019486378.1 NZ_CP061778:c6689119-6688772 [Pseudomonas aeruginosa]
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
MSPVVIRFTDTAEQSIEDQVHHLAPFQGEQAALQSVLSLLDEIEEKISLAPKGYPVSQQASLLGVLSYRELNTGPYRVFY
EFHEEQGEAAVILVLRQKQSVEQQLIRYCLVGPIE
Download Length: 348 bp
>T172991 NZ_CP080070:2681625-2681732 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCGGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAGTAA
Antitoxin
Download Length: 84 a.a. Molecular weight: 9442.79 Da Isoelectric Point: 9.4808
>AT172991 WP_003114155.1 NZ_CP061778:c6689380-6689129 [Pseudomonas aeruginosa]
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
MRVETISYLKRHAADLDLSEPMVVTQNGVPAYVVESYAERKQRDEAIALVKLLAIGSRQYAEGKHRSVDDLKARLSRRFA
QPE
Download Length: 252 bp
>AT172991 NZ_CP080070:c2681578-2681512 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
TGTCTGGTTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A444LUU5 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0B0C355 |