Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RHH(antitoxin)
Location 1879362..1879867 Replicon chromosome
Accession NZ_CP061778
Organism Pseudomonas aeruginosa strain ZBX-P13

Toxin (Protein)


Gene name parE Uniprot ID A0A3S3VVC5
Locus tag IFJ79_RS08755 Protein ID WP_031640969.1
Coordinates 1879362..1879643 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A1C7BDS9
Locus tag IFJ79_RS08760 Protein ID WP_003083775.1
Coordinates 1879640..1879867 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ79_RS08730 (IFJ79_08730) 1874613..1875962 + 1350 WP_003137006.1 C4-dicarboxylate transporter DctA -
IFJ79_RS08735 (IFJ79_08735) 1876011..1876697 + 687 WP_003083762.1 FadR/GntR family transcriptional regulator -
IFJ79_RS08740 (IFJ79_08740) 1876798..1877532 + 735 WP_003128333.1 GntR family transcriptional regulator -
IFJ79_RS08745 (IFJ79_08745) 1877712..1878122 + 411 WP_003110659.1 aegerolysin family protein -
IFJ79_RS08750 (IFJ79_08750) 1878154..1879062 - 909 WP_033990895.1 LysR family transcriptional regulator -
IFJ79_RS08755 (IFJ79_08755) 1879362..1879643 - 282 WP_031640969.1 type II toxin-antitoxin system toxin ParE Toxin
IFJ79_RS08760 (IFJ79_08760) 1879640..1879867 - 228 WP_003083775.1 CopG family ribbon-helix-helix protein Antitoxin
IFJ79_RS08765 (IFJ79_08765) 1880043..1880663 - 621 WP_003101226.1 hypothetical protein -
IFJ79_RS08770 (IFJ79_08770) 1880764..1881264 + 501 WP_003101228.1 LEA type 2 family protein -
IFJ79_RS08775 (IFJ79_08775) 1881336..1881677 + 342 WP_003101229.1 zinc ribbon domain-containing protein YjdM -
IFJ79_RS08780 (IFJ79_08780) 1881759..1883186 - 1428 WP_003083784.1 GABA permease -
IFJ79_RS08785 (IFJ79_08785) 1883355..1884848 - 1494 WP_003101230.1 CoA-acylating methylmalonate-semialdehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-87)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10475.19 Da        Isoelectric Point: 10.0435

>T172987 WP_031640969.1 NZ_CP061778:c1879643-1879362 [Pseudomonas aeruginosa]
MSLKWTRKAAADLDAIYDHYVVLIGPEKALKAVQDIVEQVKPLQQVANQGAGRPSEVPGVRTLNLERWPFSAPFRVKGKE
IQILRIDRVEITP

Download         Length: 282 bp

>T172987 NZ_CP080070:1816153-1816407 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8556.58 Da        Isoelectric Point: 5.5740

>AT172987 WP_003083775.1 NZ_CP061778:c1879867-1879640 [Pseudomonas aeruginosa]
MSTVVSFRADDALVAALDELARATHRDRPYHLRQALAQYLERQQWQVAAIDEGLADANAGRLLEHTEIEKRWGLQ

Download         Length: 228 bp

>AT172987 NZ_CP080070:1815905-1816156 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3S3VVC5

Antitoxin

Source ID Structure
AlphaFold DB A0A1C7BDS9

References