Detailed information of TA system TA172986

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relB-parE/ParE-RHH
• Location: 1796773..1797341
• Replicon: chromosome
• Accession: NZ_CP061778
• Organism: Pseudomonas aeruginosa strain ZBX-P13

Toxin (Protein)

• Gene name: parE
• Uniprot ID: A0A0D0R3P1
• Locus tag: IFJ79_RS08355
• Protein ID: WP_011222050.1
• Coordinates: 1797048..1797341 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A6M3UV67
• Locus tag: IFJ79_RS08350
• Protein ID: WP_011222051.1
• Coordinates: 1796773..1797060 (+)
• Length: 96 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ79_RS08325 (IFJ79_08320)	1792049..1792888	+	840	WP_000259031.1	sulfonamide-resistant dihydropteroate synthase Sul1	-
IFJ79_RS08330 (IFJ79_08325)	1793016..1793516	+	501	WP_000376623.1	GNAT family N-acetyltransferase	-
IFJ79_RS08335 (IFJ79_08330)	1793485..1794477	-	993	WP_001381192.1	TniB family NTP-binding protein	-
IFJ79_RS08340 (IFJ79_08335)	1794480..1796159	-	1680	WP_000179844.1	DDE-type integrase/transposase/recombinase	-
IFJ79_RS08345 (IFJ79_08340)	1796394..1796600	+	207	WP_033991586.1	hypothetical protein	-
IFJ79_RS08350 (IFJ79_08345)	1796773..1797060	+	288	WP_011222051.1	CopG family ribbon-helix-helix protein	Antitoxin
IFJ79_RS08355 (IFJ79_08350)	1797048..1797341	+	294	WP_011222050.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IFJ79_RS31975 (IFJ79_08355)	1797279..1797590	-	312	WP_052150402.1	hypothetical protein	-
IFJ79_RS08365 (IFJ79_08360)	1797626..1797814	-	189	Protein_1652	multidrug transporter	-
IFJ79_RS08370 (IFJ79_08365)	1798240..1798482	+	243	WP_000844627.1	transposase	-
IFJ79_RS08375 (IFJ79_08370)	1798514..1799164	-	651	WP_000164043.1	tetracycline resistance transcriptional repressor TetR(A)	-
IFJ79_RS08380 (IFJ79_08375)	1799270..1800460	+	1191	WP_033991588.1	tetracycline efflux MFS transporter Tet(A)	-
IFJ79_RS08385 (IFJ79_08380)	1801194..1802093	-	900	WP_032494864.1	extended-spectrum class A beta-lactamase VEB-9	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaOXA-10 / ant(3'')-Ia / sul1 / tet(A) / blaVEB-1	-	1740595..1816995	76400

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-94)

Antitoxin

• Ribbon-helix-helix protein, CopG (9-45)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10890.71 Da
• Isoelectric Point: 10.8518

>T172986 WP_011222050.1 NZ_CP061778:1797048-1797341 [Pseudomonas aeruginosa]
MPQVILSPAALRDLKRLREFLHSKSPVVAQRAAQTIRSALAQLGQQPAMGRPIEGLPEVFREWVIPFGDSGYLARYRLEG
ETVVILALRHQREAGFI

Nucleotide

• Length: 294 bp

>T172986 NZ_CP080070:1815905-1816156 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCCCTGGAGGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCTGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Antitoxin

Protein

• Length: 96 a.a.
• Molecular weight: 10922.19 Da
• Isoelectric Point: 5.1897

>AT172986 WP_011222051.1 NZ_CP061778:1796773-1797060 [Pseudomonas aeruginosa]
MSAATKPMSIKLDSDTQSRIKQLAAARDRSAHWMMREAITQYVEREERKEAFRRDTLDAWQEFQETGLHVSLEETDQWLA
GWGTEIEGGAPACHK

Nucleotide

• Length: 288 bp

>AT172986 NZ_CP080070:1816153-1816407 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCAGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Toxin

• AlphaFold DB: A0A0D0R3P1

Antitoxin

• AlphaFold DB: A0A6M3UV67