Detailed information of TA system TA172981

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Xre(antitoxin)
• Location: 4653184..4654442
• Replicon: chromosome
• Accession: NZ_CP061777
• Organism: Pseudomonas aeruginosa strain ZBX-P23

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: IFJ80_RS21740
• Protein ID: WP_003163133.1
• Coordinates: 4653184..4653939 (-)
• Length: 252 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: V6AJU7
• Locus tag: IFJ80_RS21745
• Protein ID: WP_003086329.1
• Coordinates: 4654074..4654442 (-)
• Length: 123 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ80_RS21730 (IFJ80_21725)	4648356..4650899	+	2544	WP_003163132.1	acyl-homoserine-lactone acylase QuiP	-
IFJ80_RS21735 (IFJ80_21730)	4651054..4652415	-	1362	WP_003081943.1	DNA recombination protein RmuC	-
IFJ80_RS21740 (IFJ80_21735)	4653184..4653939	-	756	WP_003163133.1	RES family NAD+ phosphorylase	Toxin
IFJ80_RS21745 (IFJ80_21740)	4654074..4654442	-	369	WP_003086329.1	DUF2384 domain-containing protein	Antitoxin
IFJ80_RS21750 (IFJ80_21745)	4654515..4655801	-	1287	WP_003163134.1	FAD-binding oxidoreductase	-
IFJ80_RS21755 (IFJ80_21750)	4655857..4657350	-	1494	WP_277915554.1	aldehyde dehydrogenase family protein	-
IFJ80_RS21760 (IFJ80_21755)	4657525..4658001	+	477	WP_003163135.1	hypothetical protein	-
IFJ80_RS21765 (IFJ80_21760)	4658004..4658279	-	276	WP_010792073.1	zinc ribbon domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (63-207)

Antitoxin

• Cro/C1-type helix-turn-helix domain (23-47)

Sequences

Toxin

Protein

• Length: 252 a.a.
• Molecular weight: 28250.37 Da
• Isoelectric Point: 7.7294

>T172981 WP_003163133.1 NZ_CP061777:c4653939-4653184 [Pseudomonas aeruginosa]
VSEIWRQCKGERHIRPLQGRLVRLVESQEQVATLQLVDTLEEQALLEELLESSKPPVPADAEPLHYLLKTPFRYPPLRWG
SRFGRRHEPSLFYAALKLETAMAESAYYRCVLWSGMAVPPPSGRILSEHASFEAGWKVERGIRLQAPPFSDHEAALTDIA
DYRAPQELGSAMRSAGVQAFEYRSARCPERGCNVALFTPAAFTEKRPRNLTPWLCETTAGYVAFKPAHVPGSPKIFSWEL
FLVDGKLPHPA

Nucleotide

• Length: 756 bp

>T172981 NZ_CP080070:199906-200013 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Protein

• Length: 123 a.a.
• Molecular weight: 13367.63 Da
• Isoelectric Point: 9.9874

>AT172981 WP_003086329.1 NZ_CP061777:c4654442-4654074 [Pseudomonas aeruginosa]
MSALIKERPSADAVLAKAVLAAREQLGLTQLELAGIVGVDRSAISRWKTQGLRVDSKTGELALLLVRVYRALYALFGGQQ
EDMRHFLRTPNHHLAGEPLALMGQVQGLVHVLEYLDAIRGKV

Nucleotide

• Length: 369 bp

>AT172981 NZ_CP080070:c199858-199792 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Structures

Antitoxin

• AlphaFold DB: V6AJU7