Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 2632619..2633661 | Replicon | chromosome |
| Accession | NZ_CP061777 | ||
| Organism | Pseudomonas aeruginosa strain ZBX-P23 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | IFJ80_RS12595 | Protein ID | WP_003109777.1 |
| Coordinates | 2633086..2633661 (+) | Length | 192 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | I3TV68 |
| Locus tag | IFJ80_RS12590 | Protein ID | WP_003050245.1 |
| Coordinates | 2632619..2633089 (+) | Length | 157 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IFJ80_RS12555 (IFJ80_12555) | 2628011..2629429 | - | 1419 | WP_003109776.1 | TIGR03752 family integrating conjugative element protein | - |
| IFJ80_RS12560 (IFJ80_12560) | 2629419..2630330 | - | 912 | WP_003105643.1 | TIGR03749 family integrating conjugative element protein | - |
| IFJ80_RS12565 (IFJ80_12565) | 2630327..2631019 | - | 693 | WP_003105641.1 | TIGR03746 family integrating conjugative element protein | - |
| IFJ80_RS12570 (IFJ80_12570) | 2631016..2631414 | - | 399 | WP_003105639.1 | TIGR03750 family conjugal transfer protein | - |
| IFJ80_RS12575 (IFJ80_12575) | 2631426..2631785 | - | 360 | WP_003090173.1 | TIGR03745 family integrating conjugative element membrane protein | - |
| IFJ80_RS12580 (IFJ80_12580) | 2631802..2632035 | - | 234 | WP_003050225.1 | TIGR03758 family integrating conjugative element protein | - |
| IFJ80_RS12585 (IFJ80_12585) | 2632032..2632415 | - | 384 | WP_003105635.1 | RAQPRD family integrative conjugative element protein | - |
| IFJ80_RS12590 (IFJ80_12590) | 2632619..2633089 | + | 471 | WP_003050245.1 | helix-turn-helix domain-containing protein | Antitoxin |
| IFJ80_RS12595 (IFJ80_12595) | 2633086..2633661 | + | 576 | WP_003109777.1 | PIN domain-containing protein | Toxin |
| IFJ80_RS12600 (IFJ80_12600) | 2633679..2634593 | + | 915 | WP_003105629.1 | AAA family ATPase | - |
| IFJ80_RS12605 (IFJ80_12605) | 2634590..2635060 | + | 471 | WP_003105626.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap8 | - |
| IFJ80_RS12610 (IFJ80_12610) | 2635057..2635557 | + | 501 | WP_003090159.1 | type III CBASS phage resistance system CD-NTase-associated protein Cap7 | - |
| IFJ80_RS12615 (IFJ80_12615) | 2635557..2636459 | + | 903 | WP_003105624.1 | CBASS oligonucleotide cyclase | - |
| IFJ80_RS12620 (IFJ80_12620) | 2636498..2637223 | + | 726 | WP_003050273.1 | CBASS effector endonuclease NucC | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | - | - | 2582775..2676648 | 93873 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 192 a.a. Molecular weight: 21644.79 Da Isoelectric Point: 5.6172
>T172979 WP_003109777.1 NZ_CP061777:2633086-2633661 [Pseudomonas aeruginosa]
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
MRHSPFTAVYDACVLYPAPLRDFLMWLGLSGRFRARWSQAIHEEWKRNLLINRPDLTRVQVDRTSDLMDRAIPDGLVEGY
EALVAGLTLPDPDDRHVLAAAIRCGASVIVTFNERDFPNDLLAPYGIESQHPDEFVDNLLDLDAAAVVSAAQRQRAQLKH
PPIEVDRYLEILLRQGLVQTTKVLATYRTIL
Download Length: 576 bp
>T172979 NZ_CP080068:31720-32001 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA
Antitoxin
Download Length: 157 a.a. Molecular weight: 17245.62 Da Isoelectric Point: 6.3803
>AT172979 WP_003050245.1 NZ_CP061777:2632619-2633089 [Pseudomonas aeruginosa]
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
MTTATAQSKMTLPAAGEVKAAVQGQRALAAYLATQFETQHIQIFDDHKQAHQVELPTSALRLLVDILAELADGNAVKVVP
VHAELTTQEAADLLNVSRPHFVKLLEDGVLAFHRTGKHRRVRFADLMQYKEARERASEQAMAELAQQSQELGMGYE
Download Length: 471 bp
>AT172979 NZ_CP080068:31479-31730 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA
ATGAGCTATCAAATTCTGACAACTACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|