Detailed information of TA system TA172978

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 2359456..2359972
• Replicon: chromosome
• Accession: NZ_CP061777
• Organism: Pseudomonas aeruginosa strain ZBX-P23

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IFJ80_RS11405
• Protein ID: WP_071557699.1
• Coordinates: 2359691..2359972 (+)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A482UCX2
• Locus tag: IFJ80_RS11400
• Protein ID: WP_033942931.1
• Coordinates: 2359456..2359701 (+)
• Length: 82 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ80_RS11385 (IFJ80_11385)	2355182..2358349	+	3168	WP_033942936.1	helicase-related protein	-
IFJ80_RS11390 (IFJ80_11390)	2358473..2358931	+	459	Protein_2251	hypothetical protein	-
IFJ80_RS11395 (IFJ80_11395)	2358849..2359274	-	426	WP_227495363.1	hypothetical protein	-
IFJ80_RS11400 (IFJ80_11400)	2359456..2359701	+	246	WP_033942931.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IFJ80_RS11405 (IFJ80_11405)	2359691..2359972	+	282	WP_071557699.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IFJ80_RS11410 (IFJ80_11410)	2360226..2360723	-	498	WP_033942928.1	DNA repair protein RadC	-
IFJ80_RS11415 (IFJ80_11415)	2360734..2361645	-	912	WP_033942927.1	hypothetical protein	-
IFJ80_RS11420 (IFJ80_11420)	2361738..2362742	-	1005	WP_033942926.1	YqaJ viral recombinase family protein	-
IFJ80_RS11425 (IFJ80_11425)	2362817..2363785	-	969	WP_033942925.1	DUF932 domain-containing protein	-
IFJ80_RS33595	2363845..2364177	-	333	WP_071557700.1	hypothetical protein	-
IFJ80_RS11430 (IFJ80_11430)	2364612..2364809	+	198	WP_232092115.1	AlpA family phage regulatory protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-82)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10721.55 Da
• Isoelectric Point: 10.6485

>T172978 WP_071557699.1 NZ_CP061777:2359691-2359972 [Pseudomonas aeruginosa]
MTYKLEFLPSALKEWEKLGHTVREQAKKKLRERLEAPKVQADALRDLPGHYKIKLRTAGYRLVYNVEDDRVVVIVVAVGK
RERSAAYKAAGKR

Nucleotide

• Length: 282 bp

>T172978 NZ_CP080066:c4534387-4534076 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTTTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 82 a.a.
• Molecular weight: 8653.98 Da
• Isoelectric Point: 4.1469

>AT172978 WP_033942931.1 NZ_CP061777:2359456-2359701 [Pseudomonas aeruginosa]
MQSVLADVAVSVSELKKNPTGVMAGAGGMPVAVLNHNRVMGYMVPAELYEQMLDRLDDLDLIDVVNARSGEKGVPVNLDD
L

Nucleotide

• Length: 246 bp

>AT172978 NZ_CP080066:c4534075-4533785 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
GCGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCTGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Antitoxin

• AlphaFold DB: A0A482UCX2