Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4695499..4696334 | Replicon | chromosome |
| Accession | NZ_CP061764 | ||
| Organism | Escherichia coli O19:H7 strain 730V1 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A7W4PV54 |
| Locus tag | ID627_RS23190 | Protein ID | WP_000854821.1 |
| Coordinates | 4695499..4695876 (-) | Length | 126 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | - |
| Locus tag | ID627_RS23195 | Protein ID | WP_032216526.1 |
| Coordinates | 4695966..4696334 (-) | Length | 123 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| ID627_RS23160 | 4690558..4690830 | + | 273 | WP_001548030.1 | type V toxin-antitoxin system endoribonuclease antitoxin GhoS | - |
| ID627_RS23165 | 4690841..4691538 | - | 698 | Protein_4563 | IS1 family transposase | - |
| ID627_RS23170 | 4691866..4693404 | - | 1539 | WP_001187167.1 | lysine decarboxylation/transport transcriptional activator CadC | - |
| ID627_RS23175 | 4694153..4694995 | - | 843 | WP_001529559.1 | DUF4942 domain-containing protein | - |
| ID627_RS23180 | 4695080..4695277 | - | 198 | WP_023563519.1 | DUF957 domain-containing protein | - |
| ID627_RS23185 | 4695305..4695502 | - | 198 | Protein_4567 | hypothetical protein | - |
| ID627_RS23190 | 4695499..4695876 | - | 378 | WP_000854821.1 | type IV toxin-antitoxin system toxin CbtA | Toxin |
| ID627_RS23195 | 4695966..4696334 | - | 369 | WP_032216526.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| ID627_RS23200 | 4696353..4696997 | - | 645 | Protein_4570 | antitoxin of toxin-antitoxin stability system | - |
| ID627_RS23205 | 4697016..4697237 | - | 222 | WP_001601167.1 | DUF987 domain-containing protein | - |
| ID627_RS23210 | 4697306..4697782 | - | 477 | WP_001186724.1 | RadC family protein | - |
| ID627_RS23215 | 4697798..4698280 | - | 483 | WP_001508976.1 | antirestriction protein | - |
| ID627_RS23220 | 4698372..4699190 | - | 819 | WP_191113443.1 | DUF945 domain-containing protein | - |
| ID627_RS23225 | 4699289..4699522 | - | 234 | WP_191113444.1 | DUF905 family protein | - |
| ID627_RS23230 | 4699528..4700205 | - | 678 | WP_001097364.1 | hypothetical protein | - |
| ID627_RS23235 | 4700324..4701208 | - | 885 | WP_032216515.1 | 50S ribosome-binding GTPase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | - | - | 4690841..4747288 | 56447 | |
| - | flank | IS/Tn | - | - | 4690841..4691218 | 377 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 126 a.a. Molecular weight: 13930.95 Da Isoelectric Point: 8.5163
>T172973 WP_000854821.1 NZ_CP061764:c4695876-4695499 [Escherichia coli O19:H7]
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
MKTLPVLPGQAASSRPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKHPGAKQ
Download Length: 378 bp
>T172973 NZ_CP080066:c3620322-3619945 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCTGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGCTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCCGGCATTTCACTGTGCGATGCAGTGAACTTTCTTGTTGAAAAATACGCGCTGGTGCGTACCGACCAGCTGGAATTC
AGTGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGAGCTCGCCGGGCGACTGGCCTGATGACCCGCGA
CAATTACCGAACGGTAAATAACATTACCCTGGGTAAGTATCAGGAGGCGAAACGATGA
Antitoxin
Download Length: 123 a.a. Molecular weight: 13810.69 Da Isoelectric Point: 6.2066
>AT172973 WP_032216526.1 NZ_CP061764:c4696334-4695966 [Escherichia coli O19:H7]
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
VSDKLHETNYPDDHNDRLWWGLLCTVTPCFGARLVQEGNRLHYLVDRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCEADTLGSCGYVYLAVYPTPETKK
Download Length: 369 bp
>AT172973 NZ_CP080066:c3620779-3620411 [Escherichia coli]
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
GTGTCAGACACGTTCCATGAAACAAATTATCCCGACAACAACAACGATCGCCCCTGGTGGGGGCTACCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGACGCGGATGCGTACCACCTGGACCAGGCCTTTCCACTGCTGATGAAACAACTGGAGCTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|