Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4452918..4453513 Replicon chromosome
Accession NZ_CP061749
Organism Escherichia coli O15:H12 strain 2273-PO3

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag IED00_RS21545 Protein ID WP_000239581.1
Coordinates 4452918..4453268 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID L4JJX7
Locus tag IED00_RS21550 Protein ID WP_001223213.1
Coordinates 4453262..4453513 (-) Length 84 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IED00_RS21525 4448367..4449389 - 1023 WP_001548970.1 ABC transporter permease -
IED00_RS21530 4449403..4450905 - 1503 WP_001095667.1 sugar ABC transporter ATP-binding protein -
IED00_RS21535 4451043..4451999 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
IED00_RS21540 4452309..4452839 + 531 WP_000055072.1 inorganic diphosphatase -
IED00_RS21545 4452918..4453268 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
IED00_RS21550 4453262..4453513 - 252 WP_001223213.1 type II toxin-antitoxin system antitoxin ChpS Antitoxin
IED00_RS21555 4453725..4454066 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
IED00_RS21560 4454069..4457848 - 3780 WP_001548968.1 autotransporter assembly complex protein TamB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(8-114)

Antitoxin

(6-49)


Sequences


Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T172897 WP_000239581.1 NZ_CP061749:c4453268-4452918 [Escherichia coli O15:H12]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

>T172897 NZ_CP079993:c2777835-2777732 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9331.64 Da        Isoelectric Point: 4.6509

>AT172897 WP_001223213.1 NZ_CP061749:c4453513-4453262 [Escherichia coli O15:H12]
MRITIKRWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp

>AT172897 NZ_CP079993:2777694-2777965 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB V0SXT4


Antitoxin

Source ID Structure
AlphaFold DB L4JJX7

References