Detailed information of TA system TA172860

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA(toxin)
• Location: 3025099..3026882
• Replicon: chromosome
• Accession: NZ_CP061744
• Organism: Enterobacter hormaechei strain NJGLYY90-CR

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: -
• Locus tag: IFJ76_RS14600
• Protein ID: WP_058652848.1
• Coordinates: 3025099..3026448 (+)
• Length: 450 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A837FFV9
• Locus tag: IFJ76_RS14605
• Protein ID: WP_003859317.1
• Coordinates: 3026445..3026882 (+)
• Length: 146 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ76_RS14575	3020922..3021857	-	936	WP_003859306.1	tRNA dihydrouridine(16) synthase DusC	-
IFJ76_RS14580	3022026..3022421	+	396	WP_003859308.1	CidA/LrgA family protein	-
IFJ76_RS14585	3022418..3023113	+	696	WP_003859310.1	CidB/LrgB family autolysis modulator	-
IFJ76_RS14590	3023242..3024126	+	885	WP_003859312.1	cytidine deaminase	-
IFJ76_RS14595	3024254..3024964	+	711	WP_003859314.1	outer membrane permeability protein SanA	-
IFJ76_RS14600	3025099..3026448	+	1350	WP_058652848.1	type II toxin-antitoxin system HipA family toxin	Toxin
IFJ76_RS14605	3026445..3026882	+	438	WP_003859317.1	helix-turn-helix domain-containing protein	Antitoxin
IFJ76_RS14610	3026921..3027931	-	1011	WP_003859318.1	galactose/methyl galactoside ABC transporter permease MglC	-
IFJ76_RS14615	3027947..3029467	-	1521	WP_003859320.1	galactose/methyl galactoside ABC transporter ATP-binding protein MglA	-
IFJ76_RS14620	3029547..3030545	-	999	WP_017383382.1	galactose/glucose ABC transporter substrate-binding protein MglB	-
IFJ76_RS14625	3030841..3031863	-	1023	WP_003859324.1	HTH-type transcriptional regulator GalS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (166-406)

Antitoxin

• Cro/C1-type helix-turn-helix domain (75-128)

Sequences

Toxin

Protein

• Length: 450 a.a.
• Molecular weight: 51151.81 Da
• Isoelectric Point: 4.6562

>T172860 WP_058652848.1 NZ_CP061744:3025099-3026448 [Enterobacter hormaechei]
METLTVQAYLNETWTDIALIKYPGSEKNDWNTTQLDYLTEYAINFLDYDDFHAVSVNHPVSLFFDDHGQPGWLRFIDDII
PAGASRRYWINALDISELPVGQQNFLLLKFGTMSPVGNLRIKESIPEWNKFASTKTFTVADVIDRAADFLDYAQERGAAA
GGATGAGGEAPKLLLRCSETDAIWIDTWQNEPDNRDRYYLVKYPRGNRTEVDCNILRAEFHYYHEINAMGFSTIPVETMR
LEEGSHYPSLWLPRFDIVRNEQDQLVRLGMESVYSLLQKAPGTLLDHETTLRALINKITSSHMVQQQGYHFDIPGFVTEW
VRRDLLNIIFGNSDNHGRNTAFVKAENQIMLSPVYDFAPMKADPEGIPRTLKWSLSCESGGDYNFNTIAQTLAEWIPPAT
LLDALHETAVQLIDLPERLAARGVPEQIMEMPAMGFRYIPDKLSRWGLL

Nucleotide

• Length: 1350 bp

>T172860 NZ_CP079992:c830201-829860 [Escherichia coli]
ATGACTGACACGCATTCTATTGCACAACCGTTCGAAGCAGAAGTCTCCCCGGCAAATAACCGTCATGTCACCGTCGGTTA
TGCGAGTCGCTACCCGGATTACAGCCGTATTCCCGCCATCACCCTGAAAGGTCAGTGGCTGGAAGCCGCCGGTTTTGCCA
CTGGCACGGCGGTAGATGTCAAAGTGATGGAAGGCTGTATTGTCCTCACCGCCCAACCACCCGCCGCCGAGGAGAGCGAA
CTGATGCAGTCGCTACGCCAGGTGTGCAAACTGTCGGCGCGTAAACAAAAGCAGGTGCAGGCGTTTATTGGAGTGATTGC
CGGTAAACAGAAAGTCGCGTAA

Antitoxin

Protein

• Length: 146 a.a.
• Molecular weight: 16185.64 Da
• Isoelectric Point: 10.5154

>AT172860 WP_003859317.1 NZ_CP061744:3026445-3026882 [Enterobacter hormaechei]
MKTPNEAESELLQTLAQVRSVNKKRHHDEAEEPDKPSVVKRQRVTQGLTRISTLDRQAVLHAAIRDILLGKITQGEALKR
LRVEVLGLKQDEYAKLVSVSRKTLSDVENNRGNYSADVINKIFKPFGLQTGLVPVSKSLIASLFS

Nucleotide

• Length: 438 bp

>AT172860 NZ_CP079992:830196-830272 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Structures

Antitoxin

• AlphaFold DB: A0A837FFV9