Detailed information of TA system TA172851

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 2254126..2254865
• Replicon: chromosome
• Accession: NZ_CP061744
• Organism: Enterobacter hormaechei strain NJGLYY90-CR

Toxin (Protein)

• Gene name: tacT
• Uniprot ID: -
• Locus tag: IFJ76_RS10985
• Protein ID: WP_191116665.1
• Coordinates: 2254126..2254611 (-)
• Length: 162 a.a.

Antitoxin (Protein)

• Gene name: tacA
• Uniprot ID: A0A837FCR9
• Locus tag: IFJ76_RS10990
• Protein ID: WP_003857131.1
• Coordinates: 2254599..2254865 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IFJ76_RS10955	2249154..2249594	+	441	WP_003857152.1	GNAT family N-acetyltransferase	-
IFJ76_RS10960	2249740..2250735	+	996	WP_003857149.1	alpha/beta hydrolase	-
IFJ76_RS10965	2250780..2251373	+	594	Protein_2137	response regulator	-
IFJ76_RS10970	2251380..2251706	-	327	Protein_2138	GDP-mannose pyrophosphatase	-
IFJ76_RS10975	2251793..2252551	+	759	WP_129335072.1	DeoR/GlpR family DNA-binding transcription regulator	-
IFJ76_RS10980	2252656..2253948	+	1293	WP_058652202.1	glycoside hydrolase	-
IFJ76_RS10985	2254126..2254611	-	486	WP_191116665.1	GNAT family N-acetyltransferase	Toxin
IFJ76_RS10990	2254599..2254865	-	267	WP_003857131.1	DUF1778 domain-containing protein	Antitoxin
IFJ76_RS10995	2254929..2255858	-	930	WP_003857129.1	LysR family transcriptional regulator	-
IFJ76_RS11000	2255988..2257376	+	1389	WP_023314162.1	MFS transporter	-
IFJ76_RS11005	2257398..2258393	-	996	WP_003857125.1	DUF2891 domain-containing protein	-
IFJ76_RS11010	2258403..2259389	-	987	WP_003857123.1	DUF979 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (66-151)

Antitoxin

• Vibrio phage ICP1, Orf50 (6-82)

Sequences

Toxin

Protein

• Length: 162 a.a.
• Molecular weight: 17441.10 Da
• Isoelectric Point: 9.6283

>T172851 WP_191116665.1 NZ_CP061744:c2254611-2254126 [Enterobacter hormaechei]
VGRVTAPEPLSSVHQLAEFVSGEAVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTQATGNLRRNM
PDPIPVIILAGLAVDVSLRGNGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKAFYIHHGFKASQTQERTLFLRLP
Q

Nucleotide

• Length: 486 bp

>T172851 NZ_CP079991:c3741475-3741140 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10090.50 Da
• Isoelectric Point: 4.3837

>AT172851 WP_003857131.1 NZ_CP061744:c2254865-2254599 [Enterobacter hormaechei]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACQAAENVILDRRVFNFNDEQYAEFIDMLDAPVADDPAIEKLL
ARKPQWDV

Nucleotide

• Length: 267 bp

>AT172851 NZ_CP079991:c3741723-3741475 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGGGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A837FCR9