Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 1059535..1060155 Replicon chromosome
Accession NZ_CP061744
Organism Enterobacter hormaechei strain NJGLYY90-CR

Toxin (Protein)


Gene name Hha Uniprot ID A0A837FFM2
Locus tag IFJ76_RS05040 Protein ID WP_015571250.1
Coordinates 1059535..1059753 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID F5RUW7
Locus tag IFJ76_RS05045 Protein ID WP_006809850.1
Coordinates 1059781..1060155 (-) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFJ76_RS05010 1055547..1055807 + 261 WP_015571255.1 type B 50S ribosomal protein L31 -
IFJ76_RS05015 1055810..1055950 + 141 WP_003859006.1 type B 50S ribosomal protein L36 -
IFJ76_RS05020 1055947..1056657 - 711 WP_022650493.1 GNAT family N-acetyltransferase -
IFJ76_RS05025 1056759..1058219 + 1461 WP_058652690.1 PLP-dependent aminotransferase family protein -
IFJ76_RS05030 1058191..1058658 - 468 WP_022650495.1 hypothetical protein -
IFJ76_RS05035 1058775..1059326 - 552 WP_022650496.1 maltose O-acetyltransferase -
IFJ76_RS05040 1059535..1059753 - 219 WP_015571250.1 hemolysin expression modulator Hha Toxin
IFJ76_RS05045 1059781..1060155 - 375 WP_006809850.1 Hha toxicity modulator TomB Antitoxin
IFJ76_RS05050 1060666..1063812 - 3147 WP_022650497.1 multidrug efflux RND transporter permease subunit -
IFJ76_RS05055 1063835..1065028 - 1194 WP_058652691.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8583.95 Da        Isoelectric Point: 8.9008

>T172850 WP_015571250.1 NZ_CP061744:c1059753-1059535 [Enterobacter hormaechei]
MSDKPLTKVDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFVR

Download         Length: 219 bp

>T172850 NZ_CP079991:3606156-3606485 [Escherichia coli]
ATGAACACTCTACCTGCTACAATTTCGCAGGCGGCGAAGCCCTGCCTGTCGCCAGTGGCTGTCTGGCAAATGCTACTGAC
ACGCCTGCTGGAACAACACTATGGCCTGACACTGAACGACACGCCGTTCAGTGATGAAACTGTTATTAAGGAACATATCG
ATGCTGGTATCACTCTGGCCGATGCAGTCAATTTTCTGGTGGAAAAGTACGAACTGGTACGTATCGATCACAGAGGATTT
TCGTGGCAACAACAGTCTCCATATATTTCCGTAGTAGATATTCTGCGAGCAAGGCGCTCTACCGGCTTGCTAAAAACTAA
TGTGAAATAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14497.28 Da        Isoelectric Point: 4.8989

>AT172850 WP_006809850.1 NZ_CP061744:c1060155-1059781 [Enterobacter hormaechei]
MDEYSPKRHDIAQLKFLCESLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFTNVSRANPVSLSC

Download         Length: 375 bp

>AT172850 NZ_CP079991:3605818-3606135 [Escherichia coli]
ATGAGCAACACCACATGGGGCCTGCAGCGAGATATCACGCCGCGCCTGGGAGCACGTCTGGTGCAGGAGGGCAACCAGCT
GCACTATCTGGCTGACCGGGCCAGTATCACCGGTAAGTTTAGTGACGCCGAATGTCCTAAGCTGGATGTGGTATTTCCAC
ATTTTATCAGCCAGATAGAGTCGATGCTGACCACTGGTGAACTGAATCCCCGCCATGCCCAATGCGTCACCCTGTACCAC
AACGGTTTTACCTGCGAAGCCGATACTCTTGGTAGTTGCGGCTACGTATACATCGCTGTTTACCCCACTCAACGCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A837FFM2

Antitoxin

Source ID Structure
AlphaFold DB A0A837FGN8

References