Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-RelB
Location 3577302..3577831 Replicon chromosome
Accession NZ_CP061725
Organism Micromonospora craniellae strain LHW63014

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag ID554_RS15975 Protein ID WP_117229863.1
Coordinates 3577302..3577559 (-) Length 86 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID -
Locus tag ID554_RS15980 Protein ID WP_117229904.1
Coordinates 3577556..3577831 (-) Length 92 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
ID554_RS15955 3572312..3575554 + 3243 WP_117229866.1 DUF87 domain-containing protein -
ID554_RS15960 3575886..3576182 + 297 WP_117229865.1 DUF1540 domain-containing protein -
ID554_RS15965 3576281..3576808 + 528 WP_117229864.1 hypothetical protein -
ID554_RS15970 3576878..3577210 - 333 WP_191088558.1 hypothetical protein -
ID554_RS15975 3577302..3577559 - 258 WP_117229863.1 Txe/YoeB family addiction module toxin Toxin
ID554_RS15980 3577556..3577831 - 276 WP_117229904.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
ID554_RS15985 3578136..3578420 + 285 WP_117229862.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
ID554_RS15990 3578417..3578671 + 255 WP_117229861.1 Txe/YoeB family addiction module toxin -
ID554_RS15995 3578818..3579915 - 1098 WP_117229860.1 integrase core domain-containing protein -
ID554_RS16000 3580161..3581618 - 1458 WP_117229859.1 plasmid pRiA4b ORF-3 family protein -
ID554_RS16005 3581922..3582635 - 714 WP_117229858.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-82)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 10092.59 Da        Isoelectric Point: 10.2349

>T172847 WP_117229863.1 NZ_CP061725:c3577559-3577302 [Micromonospora craniellae]
VRLVFTATAWSQYLSHTDRKLVKRINDLIADVMRNGYEGIGKPEPLRGELSGFWSRRIDREHRLVYRITKEDVKIVACRY
HYGDR

Download         Length: 258 bp

>T172847 NZ_CP079991:c2943763-2943509 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGACGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACGCCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin


Download         Length: 92 a.a.        Molecular weight: 10132.19 Da        Isoelectric Point: 4.1856

>AT172847 WP_117229904.1 NZ_CP061725:c3577831-3577556 [Micromonospora craniellae]
MRTVNFTQLRQNLAAELDSVIDDAEEVVVTRSGHEPVVIVSLAEYESMKETEYLLRSPSNAAALRRSIAELEQGDTAERE
LTDPDARRDAA

Download         Length: 276 bp

>AT172847 NZ_CP079991:c2944011-2943760 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGCGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTTATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGCTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATCATTGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References