Detailed information of TA system TA172842

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE-Phd
• Location: 72179..72744
• Replicon: chromosome
• Accession: NZ_CP061721
• Organism: Pseudarthrobacter sp. BIM B-2242

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: IDT60_RS00350
• Protein ID: WP_191080438.1
• Coordinates: 72451..72744 (+)
• Length: 98 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: IDT60_RS00345
• Protein ID: WP_191080437.1
• Coordinates: 72179..72454 (+)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IDT60_RS00320	67352..67918	-	567	WP_191080432.1	recombinase family protein	-
IDT60_RS00325	68059..68700	-	642	WP_191080433.1	hypothetical protein	-
IDT60_RS00330	69107..69409	+	303	WP_191080434.1	DUF4193 domain-containing protein	-
IDT60_RS00335	69581..69910	-	330	WP_191080435.1	hypothetical protein	-
IDT60_RS00340	70178..71569	-	1392	WP_191080436.1	plasmid pRiA4b ORF-3 family protein	-
IDT60_RS00345	72179..72454	+	276	WP_191080437.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
IDT60_RS00350	72451..72744	+	294	WP_191080438.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
IDT60_RS00355	72996..73652	-	657	WP_191080439.1	TetR/AcrR family transcriptional regulator	-
IDT60_RS00360	73775..75115	+	1341	WP_191080440.1	extracellular solute-binding protein	-
IDT60_RS00365	75112..76065	+	954	WP_191080441.1	sugar ABC transporter permease	-
IDT60_RS00370	76062..76967	+	906	WP_191080442.1	carbohydrate ABC transporter permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	67352..67918	566

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (14-94)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-71)

Sequences

Toxin

Protein

• Length: 98 a.a.
• Molecular weight: 10903.45 Da
• Isoelectric Point: 9.5902

>T172842 WP_191080438.1 NZ_CP061721:72451-72744 [Pseudarthrobacter sp. BIM B-2242]
VTGTEPGDTGAWKVEVTSPALKGFRRLPEKAAAAIVEFVTGPLADNPRRLSKPLTNELLGLHTARRGDYRVLFTLDVEDH
ILYVHRIEHRSDVYKPR

Nucleotide

• Length: 294 bp

>T172842 NZ_CP079991:2363913-2364089 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATGGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 10197.36 Da
• Isoelectric Point: 4.8784

>AT172842 WP_191080437.1 NZ_CP061721:72179-72454 [Pseudarthrobacter sp. BIM B-2242]
MRTVPLSEAKDKLSALVEEADRTHEIIQITRHGHPSAVLMSADDLESLQETIHWLSRPGIREDLDQAQRDIAEGNTTSGA
DLRREFGLPPR

Nucleotide

• Length: 276 bp

>AT172842 NZ_CP079991:2364135-2364551 [Escherichia coli]
ATGCGTTATCCCGTCACTCTTACACCCGCGCCGGAAGGCGGTTATATGGTTTCTTTTGTGGATATCCCTGAAGCGTTGAC
CCAGGGCGAAACTGTCGCTGAAGCGATGGAAGCGGCAAAAGATGCTTTACTGACCGCATTTGATTTTTATTTTGAAGATA
ACGAGCTTATCCCTTTACCTTCGCCATTAAATAGTCACGATCACTTTATTGAAGTACCTTTGAGCGTCGCCTCTAAGGTA
TTGCTGTTAAATGCTTTTTTACAGTCAGAAATCACTCAGCAAGAGTTAGCCAGGCGAATTGGCAAACCTAAACAGGAGAT
TACTCGCCTATTTAACTTGCATCATGCGACAAAAATCGACGCCGTCCAGCTCGCGGCAAAGGCGCTTGGCAAAGAGTTAT
CGCTGGTGATGGTTTAA