Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | hipBA/HipA-couple_hipB |
| Location | 1209297..1210945 | Replicon | chromosome |
| Accession | NZ_CP061714 | ||
| Organism | Luteimonas sp. MC1825 | ||
Toxin (Protein)
| Gene name | HipA3 | Uniprot ID | - |
| Locus tag | IDM46_RS05590 | Protein ID | WP_185115065.1 |
| Coordinates | 1209297..1210589 (-) | Length | 431 a.a. |
Antitoxin (Protein)
| Gene name | HipB3 | Uniprot ID | - |
| Locus tag | IDM46_RS05595 | Protein ID | WP_185115066.1 |
| Coordinates | 1210586..1210945 (-) | Length | 120 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| IDM46_RS05565 | 1204781..1205113 | + | 333 | WP_185115276.1 | excalibur calcium-binding domain-containing protein | - |
| IDM46_RS05570 | 1205450..1206796 | + | 1347 | WP_185115062.1 | phosphomannomutase | - |
| IDM46_RS05575 | 1207104..1207634 | + | 531 | WP_185115063.1 | hypothetical protein | - |
| IDM46_RS05580 | 1207780..1208313 | + | 534 | WP_185115064.1 | TonB-dependent receptor | - |
| IDM46_RS05585 | 1208670..1209053 | + | 384 | WP_185115277.1 | GxxExxY protein | - |
| IDM46_RS05590 | 1209297..1210589 | - | 1293 | WP_185115065.1 | type II toxin-antitoxin system HipA family toxin | Toxin |
| IDM46_RS05595 | 1210586..1210945 | - | 360 | WP_185115066.1 | helix-turn-helix domain-containing protein | Antitoxin |
| IDM46_RS05600 | 1211142..1211387 | + | 246 | WP_185115067.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | - |
| IDM46_RS05605 | 1211384..1211770 | + | 387 | WP_185115068.1 | type II toxin-antitoxin system VapC family toxin | - |
| IDM46_RS05610 | 1211975..1213405 | - | 1431 | WP_185115069.1 | DNA photolyase family protein | - |
| IDM46_RS05615 | 1213405..1213635 | - | 231 | WP_182821620.1 | DUF378 domain-containing protein | - |
| IDM46_RS05620 | 1213670..1214203 | - | 534 | WP_185115070.1 | fasciclin domain-containing protein | - |
| IDM46_RS05625 | 1214302..1215171 | + | 870 | WP_185115071.1 | MerR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 1180064..1211770 | 31706 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 431 a.a. Molecular weight: 47642.99 Da Isoelectric Point: 7.0689
>T172837 WP_185115065.1 NZ_CP061714:c1210589-1209297 [Luteimonas sp. MC1825]
VTDATVRLWGRDIGAVSWLEDRDRAVFQYMPDFADSGIRVAPIMMPPGREPFEFPGLPREAFKGLPGMLADALPDRFGNA
LIDAWLAAQGRAPGSFNPVERLCYIGSRGMGALEFHPSLSGLPRQSRAVEIDALTRLANDVLNQRGQLAGALMGDDDRGD
LEDILRVGTSAGGARAKAVLAWNEQTGEFRSGQVKAGEGFSAWLIKFDGISDNRDKELADPQGFGLVEYAFHLLAVAAGI
DMSACRIHREGGRAHFMTRRFDRTSSGGKLHMQSLAALRHFDFNAAGAHSYEQAVETIRLLGLPALDIEQQFRRAVFNVL
IRNQDDHVKNIAFLMNRKGEWRLSPAFDVSYAYNPQGSWTHQHQMSLNGKRDHFEAEDFVRFGAFCGIKPTKARELVAEI
RTQVEGWMGFAERAGVPERRAVEIGRAMRA
VTDATVRLWGRDIGAVSWLEDRDRAVFQYMPDFADSGIRVAPIMMPPGREPFEFPGLPREAFKGLPGMLADALPDRFGNA
LIDAWLAAQGRAPGSFNPVERLCYIGSRGMGALEFHPSLSGLPRQSRAVEIDALTRLANDVLNQRGQLAGALMGDDDRGD
LEDILRVGTSAGGARAKAVLAWNEQTGEFRSGQVKAGEGFSAWLIKFDGISDNRDKELADPQGFGLVEYAFHLLAVAAGI
DMSACRIHREGGRAHFMTRRFDRTSSGGKLHMQSLAALRHFDFNAAGAHSYEQAVETIRLLGLPALDIEQQFRRAVFNVL
IRNQDDHVKNIAFLMNRKGEWRLSPAFDVSYAYNPQGSWTHQHQMSLNGKRDHFEAEDFVRFGAFCGIKPTKARELVAEI
RTQVEGWMGFAERAGVPERRAVEIGRAMRA
Download Length: 1293 bp
>T172837 NZ_CP079991:c1154906-1154565 [Escherichia coli]
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
ATGAAAACTTTACCTGCAATAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 12798.45 Da Isoelectric Point: 10.1786
>AT172837 WP_185115066.1 NZ_CP061714:c1210945-1210586 [Luteimonas sp. MC1825]
MDSYTDRHATIQASLLALGERLAQLRLARNLTQAALAREAGTSASSIKRLEAGANASLDTLLRVLQVLGLDGRLLDSLPA
PGVRPVERARLGGRERRRASTPAETPKATDWAWGEDDSP
MDSYTDRHATIQASLLALGERLAQLRLARNLTQAALAREAGTSASSIKRLEAGANASLDTLLRVLQVLGLDGRLLDSLPA
PGVRPVERARLGGRERRRASTPAETPKATDWAWGEDDSP
Download Length: 360 bp
>AT172837 NZ_CP079991:c1155244-1154927 [Escherichia coli]
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
ATGAGCAACCCTACCAGGGGCCTGCAGCGGGAGATTACACTGCGCCTGGGAGCCCGTCTGGTGCAGGAAGGCAACCGACT
GCATTATCTGGCTGACCGGGCCAGCATCACCGGCAAGTTCAGTGACATCGAATGCCGGAAGCTGGATGAAACATTCCCGC
ACTTTATCCTCCAGATGGAATCGATGCTGACCACCGGTGAACTCAGCCCCCACCATGCCCACTGCGTTACCCTGTACCAC
AACGATTTAACCTGCGAAGCCGACACCCTTGGCAGTTGCGGCTACGTATACATCGCCATTTACCCCACTCAGCGTTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|