Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA(toxin)
Location 16102..16682 Replicon plasmid p7E072658
Accession NZ_CP061707
Organism Acinetobacter baumannii strain E-072658

Toxin (Protein)


Gene name hicA Uniprot ID A0A7H8SLW2
Locus tag H2787_RS18215 Protein ID WP_044425274.1
Coordinates 16102..16350 (+) Length 83 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID A0A7H8SKS1
Locus tag H2787_RS18220 Protein ID WP_035270373.1
Coordinates 16347..16682 (+) Length 112 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2787_RS18195 (H2787_18190) 11946..13187 + 1242 WP_004826931.1 group II intron reverse transcriptase/maturase -
H2787_RS18200 (H2787_18195) 13664..14557 + 894 WP_004889713.1 replication initiation protein RepM -
H2787_RS18205 (H2787_18200) 14621..15184 + 564 WP_223106964.1 plasmid replication DNA-binding protein -
H2787_RS18210 (H2787_18205) 15469..15996 + 528 WP_000537572.1 plasmid pRiA4b ORF-3 family protein -
H2787_RS18215 (H2787_18210) 16102..16350 + 249 WP_044425274.1 type II toxin-antitoxin system HicA family toxin Toxin
H2787_RS18220 (H2787_18215) 16347..16682 + 336 WP_035270373.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H2787_RS18225 (H2787_18220) 17083..17898 + 816 WP_001043260.1 sulfonamide-resistant dihydropteroate synthase Sul2 -
H2787_RS18230 (H2787_18225) 17985..18194 + 210 Protein_21 phosphoglucosamine mutase -
H2787_RS18235 (H2787_18230) 18352..18564 - 213 WP_080632801.1 helix-turn-helix transcriptional regulator -
H2787_RS18240 (H2787_18235) 18723..19091 - 369 WP_223106965.1 LysR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid sul2 - 1..19661 19661


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(20-78)

Antitoxin

Uncharacterised protein family HicB

(54-102)


Sequences

Toxin        


Download         Length: 83 a.a.        Molecular weight: 9451.04 Da        Isoelectric Point: 10.3195

>T172832 WP_044425274.1 NZ_CP061707:16102-16350 [Acinetobacter baumannii]
MGKTEKLLEKFGNSKNTFPYKDLVVLLNQLGYEKFEMAGSRVRFFNTKTEHMILLHRPHPENEIKGGALKSVKQALKQEG
FL

Download         Length: 249 bp

>T172832 NZ_CP079991:699053-699403 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin


Download         Length: 112 a.a.        Molecular weight: 12411.14 Da        Isoelectric Point: 4.7146

>AT172832 WP_035270373.1 NZ_CP061707:16347-16682 [Acinetobacter baumannii]
MSYLKYKGYLGTIEPDLETGELFGKLAFIRDLITYEAETLKTLEQAFQESVDGYLESCAELGKKPDQPFKGTFNVRISPE
LHRKAVLASSDNSLNAFVSDAIQEKLMRLGA

Download         Length: 336 bp

>AT172832 NZ_CP079991:698808-699059 [Escherichia coli]
ATGCGTATTACCATAAAAAGATGGGGGAACAGTGCAGGTATGGTCATTCCCAATATCGTAATGAAAGAACTTAACTTACA
GCCGGGGCAGAGCGTGGAGGCGCAAGTGAGCAACAATCAACTGATTCTGACACCCATCTCCAGGCGCTACTCGCTTGATG
AACTGCTGGCACAGTGTGACATGAACGCCGCGGAACTTAGCGAGCAGGATGTCTGGGGTAAATCCACCCCTGCGGGTGAC
GAAATATGGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H8SLW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7H8SKS1

References