Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-YefM
Location 41604..42175 Replicon plasmid p8E072658
Accession NZ_CP061706
Organism Acinetobacter baumannii strain E-072658

Toxin (Protein)


Gene name parE Uniprot ID Q07XG2
Locus tag H2787_RS17735 Protein ID WP_011638897.1
Coordinates 41864..42175 (+) Length 104 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q07XG1
Locus tag H2787_RS17730 Protein ID WP_011638898.1
Coordinates 41604..41864 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2787_RS17710 (H2787_17705) 37919..38254 - 336 WP_004780063.1 IS66 family insertion sequence element accessory protein TnpB -
H2787_RS17715 (H2787_17710) 38251..38634 - 384 WP_127801900.1 transposase -
H2787_RS17720 (H2787_17715) 39056..40681 - 1626 WP_223106954.1 phosphoethanolamine--lipid A transferase MCR-4.7 -
H2787_RS17725 (H2787_17720) 40855..41434 - 580 Protein_41 recombinase family protein -
H2787_RS17730 (H2787_17725) 41604..41864 + 261 WP_011638898.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
H2787_RS17735 (H2787_17730) 41864..42175 + 312 WP_011638897.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
H2787_RS17740 (H2787_17735) 42199..45285 + 3087 WP_223106955.1 Tn3 family transposase -
H2787_RS17745 (H2787_17740) 45686..46135 + 450 WP_228750196.1 hypothetical protein -
H2787_RS17750 (H2787_17745) 46282..46491 + 210 WP_228199412.1 hypothetical protein -
H2787_RS17755 (H2787_17750) 46497..47048 + 552 WP_000755487.1 macro domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid mcr-4.3 - 1..119750 119750


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-62)


Sequences

Toxin        


Download         Length: 104 a.a.        Molecular weight: 11830.64 Da        Isoelectric Point: 8.5341

>T172828 WP_011638897.1 NZ_CP061706:41864-42175 [Acinetobacter baumannii]
MPVTYHLTPDAQSDLIGIHRFTLAQWGTTQSKTYLSGLRQTIQLLAETPTLGKNRPEVRVNVFSFPYSSHVIYYIQHEHQ
FVVFGILHKSMVPLAHLAEREII

Download         Length: 312 bp

>T172828 NZ_CP079984:c1840835-1840692 [Macrococcus bohemicus]
ATGTCAACATCACATGATAATAAAAATGAAATGGTAACTGATTTCGACGACGTTGTAGAATTAGGTAAAGAGATGGAGCA
AATCTCTGAACAAAATGCTGAAGCGCGAGAAGAAGGCCAGGAACAAGAGGATGATCCTCAATAA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9330.74 Da        Isoelectric Point: 6.4546

>AT172828 WP_011638898.1 NZ_CP061706:41604-41864 [Acinetobacter baumannii]
MNTLSANEAKIHFGDLLLKAQQAPIQINKNGKPVAVVISADAYQSIETLKLHLLQSKAVKAMTDIKMGNLVDGNTFFDEL
AAGQYD

Download         Length: 261 bp

>AT172828 NZ_CP079984:c1841459-1840848 [Macrococcus bohemicus]
ATGGCAATGAATTTTAAAATTTTTGAAGATAAATTAACCGTATCGAACTACGTTGCTGATTTATTTAGAAAGCAGATGAG
TAACAATCCGACATCAATTATCGCGACTGCTTTAGGTGATGAAGCAGGTCACGTCATTGCAGAATTAAAGGCTAATATCG
CTCGTAATCCAGTTGAGACGAGTCAAATTCATATCTTTGACTATGATAAATTACGTGGTGATTATGGCACTGTTGGTATC
GTTGATAAACAATACCATGAAGCAACAGGTAAAGATATTATGGAATTGATTAAAGACGAAGCGAAGACTAAAGAGAACAA
AGGGAAGTTGACAACTTTATTTGCTACGATTACACAAGATGGCTCTGTCGGTTATAAAGAGATTAATCAGGATAACGATA
AAGGTTTACGTTCAGCACGTGAAATTATTATCGTATTAACAGGTGCAGACAAAGCTTCAATCGTTGAAAAACTATACAAT
ACTGAAGCGGGTGGCAACTTTGAAGCAGCGAATTTAAAAACACATCGCATGGTCAATGTTATCTTAGATGATGCAGCAGC
AGCTGGATTACCTCAAGATATACGTGAATACTACTTCCAAAAATTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A883CRN5

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZVH1

References