Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1288913..1289564 Replicon chromosome
Accession NZ_CP061705
Organism Acinetobacter baumannii strain E-072658

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag H2787_RS06595 Protein ID WP_000838150.1
Coordinates 1288913..1289095 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag H2787_RS06600 Protein ID WP_000966686.1
Coordinates 1289160..1289564 (+) Length 135 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2787_RS06550 (H2787_06550) 1284491..1284847 + 357 WP_140947900.1 HeH/LEM domain-containing protein -
H2787_RS06555 (H2787_06555) 1284851..1285231 + 381 WP_004793724.1 hypothetical protein -
H2787_RS06560 (H2787_06560) 1285232..1285600 + 369 WP_000524231.1 hypothetical protein -
H2787_RS06565 (H2787_06565) 1285609..1286013 + 405 WP_000248323.1 hypothetical protein -
H2787_RS06570 (H2787_06570) 1285985..1286353 + 369 WP_000539752.1 hypothetical protein -
H2787_RS06575 (H2787_06575) 1286355..1286753 + 399 WP_001132270.1 hypothetical protein -
H2787_RS06580 (H2787_06580) 1286755..1286967 + 213 WP_000121166.1 hypothetical protein -
H2787_RS06585 (H2787_06585) 1287075..1288004 + 930 WP_223106859.1 phage tail tube protein -
H2787_RS06590 (H2787_06590) 1288048..1288581 + 534 WP_001185622.1 hypothetical protein -
H2787_RS06595 (H2787_06595) 1288913..1289095 + 183 WP_000838150.1 type II toxin-antitoxin system HicA family toxin Toxin
H2787_RS06600 (H2787_06600) 1289160..1289564 + 405 WP_000966686.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
H2787_RS06605 (H2787_06605) 1289633..1290178 + 546 WP_014538368.1 DUF4468 domain-containing protein -
H2787_RS06610 (H2787_06610) 1290275..1294264 + 3990 WP_223106860.1 tape measure protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - adeH 1255624..1319805 64181


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6622.83 Da        Isoelectric Point: 10.7364

>T172826 WP_000838150.1 NZ_CP061705:1288913-1289095 [Acinetobacter baumannii]
VKSLDLVKMIEADGWYLVRVKGSHHHFKHPTKGGLVTIPHPKKELPSGTVKSILKQAGLN

Download         Length: 183 bp

>T172826 NZ_CP079981:c2088302-2087940 [Macrococcus bohemicus]
ATGAAACGAGGCGATGTTTATTTAGCTGATTTGTCACCTGTTAAAGGTTCAGAGCAAGGCGGTAAACGACCTGTAGTAAT
CATTCAAAATGACATAGGAAATAAATATAGTCCGACGGTTATAGTTGCAGCTATCACTGCTAAAATCAATAAATCAAAAA
TCCCAACGCACGTAGAGATTGGTAAGACCAATCATCATCTAGATAAAGATTCTGTGATTTTATTAGAACAAATAAGAACA
ATTGATAAAAATCGACTTATTGAAAAATTGACTTACCTGCCAAAAGAAAAGATGGAGGAAGTTGATGCAGCACTAGCAAT
TAGTCTTAATTTATCTATTGATGACTCGGAGACTTTAGGCTAA

Antitoxin


Download         Length: 135 a.a.        Molecular weight: 14587.55 Da        Isoelectric Point: 4.4082

>AT172826 WP_000966686.1 NZ_CP061705:1289160-1289564 [Acinetobacter baumannii]
MLYPIAIERGNDTEAYGVTVPDIPGCFSAGDTLDEAIENVKEAISGHLEILAEDGEEIPLASDVSKFIDDADYKGMIWAV
TEVDVSRYLGKPEKINVTLPSRLIHIIDENVGKGKRFKTRSAFLAAGAEKLLHA

Download         Length: 405 bp

>AT172826 NZ_CP079981:c2088449-2088303 [Macrococcus bohemicus]
ATGAGTAAACTACTAGAACAACAATTGATTGAAGGTTATCAATCAATGGCTGAAATTAATCTGTTAATTGCTTCAGAACA
TTATCTCCTTGAATGTGAAGTGTATGATAATGTGGATCATATGTCAGTACAAAATGATGGTGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References