Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/-
Location 465969..466622 Replicon chromosome
Accession NZ_CP061705
Organism Acinetobacter baumannii strain E-072658

Toxin (Protein)


Gene name cptA Uniprot ID A0A2S4T466
Locus tag H2787_RS02390 Protein ID WP_000607071.1
Coordinates 466233..466622 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID N9LG27
Locus tag H2787_RS02385 Protein ID WP_001288212.1
Coordinates 465969..466226 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
H2787_RS02365 (H2787_02365) 461798..462175 + 378 WP_001216380.1 50S ribosomal protein L17 -
H2787_RS02370 (H2787_02370) 462312..462575 + 264 Protein_461 transposase -
H2787_RS02375 (H2787_02380) 463072..464562 + 1491 WP_005134653.1 NAD(P)/FAD-dependent oxidoreductase -
H2787_RS02380 (H2787_02385) 464609..465781 - 1173 WP_130089813.1 acyl-CoA dehydrogenase family protein -
H2787_RS02385 (H2787_02390) 465969..466226 + 258 WP_001288212.1 succinate dehydrogenase assembly factor 2 Antitoxin
H2787_RS02390 (H2787_02395) 466233..466622 + 390 WP_000607071.1 membrane protein Toxin
H2787_RS02395 (H2787_02400) 467392..468477 + 1086 WP_223106753.1 hypothetical protein -
H2787_RS02400 (H2787_02405) 468555..469121 + 567 WP_000651536.1 rhombosortase -
H2787_RS02405 (H2787_02410) 469309..469776 + 468 Protein_468 hypothetical protein -
H2787_RS02410 (H2787_02415) 469808..471016 - 1209 WP_000343018.1 IS256-like element ISAba26 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 469808..471016 1208


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Flavinator of succinate dehydrogenase

(10-82)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 15649.98 Da        Isoelectric Point: 10.4623

>T172825 WP_000607071.1 NZ_CP061705:466233-466622 [Acinetobacter baumannii]
MINHLNFKLKYSRFSIIFQFFIGLSLAILFYQLMPLLWWLVVISLLFISFIFFLKRPQLAKIAYLDKKLWSLAYHSQNTI
SRVKILKIIDYQIFIVIYFEGHKTLTSIIWFDQMSLAEWKKLKTLEKLY

Download         Length: 390 bp

>T172825 NZ_CP079981:c1869014-1868871 [Macrococcus bohemicus]
ATGTCAACATCACATGATAATAAAAATGAAATGGTAACTGATTTCGACGACGTTGTAGAATTAGGTAAAGAGATGGAGCA
AATCTCTGAACAAAATGCTGAAGCGCGAGAAGAAGGCCAGGAACAAGAGGATGATCCTCAATAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 10332.79 Da        Isoelectric Point: 4.6247

>AT172825 WP_001288212.1 NZ_CP061705:465969-466226 [Acinetobacter baumannii]
MSEEMTLEERKVIYRARRGLKEIDVYFDPYVKNYYLKAEPAEKALFAELVEQEDPDLLDWFMEVSEPPRTELRDFIYKLK
HYVHG

Download         Length: 258 bp

>AT172825 NZ_CP079981:c1869638-1869027 [Macrococcus bohemicus]
ATGGCAATGAATTTTAAAATTTTTGAAGATAAATTAACCGTATCGAACTACGTTGCTGATTTATTTAGAAAGCAGATGAG
TAACAATCCGACATCAATTATCGCGACTGCTTTAGGTGATGAAGCAGGTCACGTCATTGCAGAATTAAAGGCTAATATCG
CTCGTAATCCAGTTGAGACGAGTCAAATTCATATCTTTGACTATGATAAATTACGTGGTGATTATGGCACTGTTGGTATC
GTTGATAAACAATACCATGAAGCAACAGGTAAAGATATTATGGAATTGATTAAAGACGAAGCGAAGACTAAAGAGAACAA
AGGGAAGTTGACAACTTTATTTGCTACGATTACACAAGATGGCTCTGTCGGTTATAAAGAGATTAATCAGGATAACGATA
AAGGTTTACGTTCAGCACGTGAAATTATTATCGTATTAACAGGTGCAGACAAAGCTTCAATCGTTGAAAAACTATACAAT
ACTGAAGCGGGTGGCAACTTTGAAGCAGCGAATTTAAAAACACATCGCATGGTCAATGTTATCTTAGATGATGCAGCAGC
AGCTGGATTACCTCAAGATATACGTGAATACTACTTCCAAAAATTTGCGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2S4T466

Antitoxin

Source ID Structure
AlphaFold DB N9LG27

References