172822

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/ParE-RHH
Location 600790..601331 Replicon chromosome
Accession NZ_CP061703
Organism Mesoflavibacter profundi strain YC1039

Toxin (Protein)


Gene name parE Uniprot ID A0A137REF7
Locus tag IFB02_RS02835 Protein ID WP_062623211.1
Coordinates 601029..601331 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A5M7B575
Locus tag IFB02_RS02830 Protein ID WP_028284019.1
Coordinates 600790..601032 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IFB02_RS02795 595837..596394 + 558 WP_106687026.1 hypothetical protein -
IFB02_RS02800 596659..597372 + 714 WP_191073026.1 hypothetical protein -
IFB02_RS02805 597586..597876 + 291 WP_106687046.1 hypothetical protein -
IFB02_RS02810 597886..598101 + 216 WP_106687025.1 hypothetical protein -
IFB02_RS02815 598254..599123 + 870 WP_106687024.1 hypothetical protein -
IFB02_RS02820 599274..599810 + 537 WP_106687023.1 YcxB family protein -
IFB02_RS02825 599966..600601 + 636 WP_106687022.1 hypothetical protein -
IFB02_RS02830 600790..601032 + 243 WP_028284019.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
IFB02_RS02835 601029..601331 + 303 WP_062623211.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IFB02_RS02840 601496..601996 + 501 WP_106687020.1 hypothetical protein -
IFB02_RS02845 602154..602801 + 648 WP_106687019.1 hypothetical protein -
IFB02_RS02850 603399..604178 - 780 WP_106687018.1 patatin-like phospholipase family protein -
IFB02_RS02855 604252..604734 - 483 WP_191073027.1 hypothetical protein -
IFB02_RS02860 604925..605359 - 435 WP_106687016.1 Hsp20/alpha crystallin family protein -
IFB02_RS02865 605450..605926 - 477 WP_106687015.1 Hsp20/alpha crystallin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 563583..610698 47115


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-94)

Antitoxin

Antitoxin ParD

(1-77)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 12257.25 Da        Isoelectric Point: 10.2010

>T172822 WP_062623211.1 NZ_CP061703:601029-601331 [Mesoflavibacter profundi]
MSKNKYRISQQAIEDLDKIWIYTLNKWSKEQADRYYDLIITEIEFIADNFMTGKSAEQTRKNYRVTKIKSHLIFYRKVEN
DIVEIVRILHQRMDIKKRLK

Download         Length: 303 bp

>T172822 NZ_CP079965:c1856546-1856196 [Macrococcus caseolyticus]
ATGAAACGCGGAGATGTTTTTTTGGCTGATCTGTCACCAGTGAAGGGATCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATAGGGAATAAATATAGTCCTACTGTGATTGTAGCGGCAATTACTGCAAAGATTAATAAGGCAAAAA
TCCCCACCCATGTTGAAATTGGCAAGGCAACGCATCGCTTAGAAAAGGATTCGGTAATACTGCTGGAACAAATTAGAACC
ATTGATAAGAATAGGTTGATTGATCATTTAACTGTGCTTGATAAGGCGAAGATGAAAGAAGTGGATACTGCACTTATAAT
TAGTTTAGGTTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9306.49 Da        Isoelectric Point: 6.8826

>AT172822 WP_028284019.1 NZ_CP061703:600790-601032 [Mesoflavibacter profundi]
MGKNTSISLGNHFEDFIREEVNSGRYGSVSEVIRSALRLLEREEKKERELIKALEVGENSGFVENFDPKQHLKELHRKHL

Download         Length: 243 bp

>AT172822 NZ_CP079965:c1856687-1856547 [Macrococcus caseolyticus]
ATGAGCCAGAAGCTAGAACAAATGCTGATAGAAGGTTATCAATCAATGGCAGAGATAAATTTATCGATAGCATCAGAACA
TTATGTATTAGAATGCGAAGTTACTGATAACCATCAGACATATACCTTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A137REF7

Antitoxin

Source ID Structure
AlphaFold DB A0A5M7B575

References