172821

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/ElaA-DUF1778
Location 62334..63085 Replicon plasmid pC39-125kb
Accession NZ_CP061702
Organism Klebsiella pneumoniae strain C39

Toxin (Protein)


Gene name ataT Uniprot ID A0A486R6L7
Locus tag IE968_RS27745 Protein ID WP_041165502.1
Coordinates 62603..63085 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6S4YWG5
Locus tag IE968_RS27740 Protein ID WP_012540170.1
Coordinates 62334..62612 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE968_RS27715 57862..58731 - 870 WP_001567390.1 DMT family transporter -
IE968_RS27720 58972..59724 + 753 WP_004729622.1 alpha/beta hydrolase -
IE968_RS27725 59775..60064 + 290 Protein_64 Tn3 family transposase -
IE968_RS27730 60171..60485 - 315 WP_023288299.1 hypothetical protein -
IE968_RS27735 61490..62026 - 537 WP_094986489.1 hypothetical protein -
IE968_RS27740 62334..62612 + 279 WP_012540170.1 DUF1778 domain-containing protein Antitoxin
IE968_RS27745 62603..63085 + 483 WP_041165502.1 GNAT family N-acetyltransferase Toxin
IE968_RS27750 63123..63527 + 405 WP_048293664.1 DUF2251 domain-containing protein -
IE968_RS27755 63847..64680 + 834 WP_012540133.1 GIY-YIG nuclease family protein -
IE968_RS27760 64744..64941 + 198 WP_077264171.1 bacteriocin immunity protein -
IE968_RS27765 65036..65272 - 237 WP_012540047.1 hypothetical protein -
IE968_RS27770 66169..67137 - 969 WP_100112216.1 IS5 family transposase -
IE968_RS27775 67217..67372 - 156 Protein_74 IS5/IS1182 family transposase -
IE968_RS27780 67403..67675 - 273 Protein_75 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..125663 125663


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17697.61 Da        Isoelectric Point: 9.4948

>T172821 WP_041165502.1 NZ_CP061702:62603-63085 [Klebsiella pneumoniae]
MGMRPPEPLTPEHNIADFCCQDQVLSEWLKKKALKNHSTGLSRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTQHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

>T172821 NZ_CP079965:c1100226-1099966 [Macrococcus caseolyticus]
ATGTACAAAGTGGTTATGAAATCTAGTGTCAAGAAAGATCTGAAGAAGATAAAAAACACACACTTAGAAACGAACTTTCT
AAAAATCATTAAACAGCTTAAAGAAAATCCATATAATAATAACCATTCTTTCGAAAAACTAATTCCCCCAATAAAGGGGT
TTTATTCGAGAAGGTTAAATGTACAACATCGTGTTGTTTATACAGTAAATGACGAAGATAAAATTGTAACAATCTATTCA
GCATATGGGCATTATGAGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10749.33 Da        Isoelectric Point: 4.6722

>AT172821 WP_012540170.1 NZ_CP061702:62334-62612 [Klebsiella pneumoniae]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFNAFVEELDAPMTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp

>AT172821 NZ_CP079965:c1100477-1100226 [Macrococcus caseolyticus]
ATGAATACTTATACACCTACAAGTGCTAGAAAAGATTTTTTCAACATTATAAAATCTGTTAATGAAGATAGTAAGGAAAT
TTACATTGCACCAACTAAAATTGGAGAAAAAGGAGCTGTTTTAGTTGGTGAAGATGATTGGAATGCCATTCAGGAGACGT
TATTCTTATTAGAAAAAGGTATTGCTTATCAAATCGAACAACGTAAAGACGAAGAAGAAATTGATTTTGACAGTACATGG
GATAATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486R6L7

Antitoxin

Source ID Structure
AlphaFold DB A0A6S4YWG5

References