Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 4889820..4891501 Replicon chromosome
Accession NZ_CP061700
Organism Klebsiella pneumoniae strain C39

Toxin (Protein)


Gene name mosT Uniprot ID A0A486LFH0
Locus tag IE968_RS23765 Protein ID WP_023328808.1
Coordinates 4889820..4890737 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID A0A486Q3T7
Locus tag IE968_RS23770 Protein ID WP_023328807.1
Coordinates 4890743..4891501 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE968_RS23745 4885126..4886646 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
IE968_RS23750 4886643..4887641 + 999 WP_031592479.1 ribose ABC transporter permease -
IE968_RS23755 4887672..4888613 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
IE968_RS23760 4888688..4889695 + 1008 WP_004178300.1 carbohydrate kinase family protein -
IE968_RS23765 4889820..4890737 - 918 WP_023328808.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
IE968_RS23770 4890743..4891501 - 759 WP_023328807.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
IE968_RS23775 4891587..4892315 - 729 WP_002885152.1 response regulator transcription factor -
IE968_RS23780 4892588..4894735 + 2148 WP_077598921.1 formate dehydrogenase subunit alpha -
IE968_RS23785 4894965..4895651 + 687 WP_004151733.1 sel1 repeat family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator AbiEi antitoxin, N-terminal domain

(1-93)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34660.13 Da        Isoelectric Point: 5.4707

>T172817 WP_023328808.1 NZ_CP061700:c4890737-4889820 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIAYLLSHNRPLVEVLSPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

>T172817 NZ_CP079950:c2019359-2019009 [Macrococcus caseolyticus]
ATGAAACGCGGAGATGTTTTTTTGGCTGATCTGTCACCAGTGAAGGGATCTGAACAAGGCGGTAAACGCCCCGTCGTTAT
TATTCAGAATAATATAGGGAATAAATATAGTCCCACTGTGATTGTAGCGGCAATTACTGCAAAGATTAATAAGGCAAAAA
TCCCCACCCATGTTGAAATTGGCAAGGCAACGCATCACTTAGAAAAGGATTCGGTAATACTGCTGGAACAAATTAGAACC
ATTGATAAGAATAGGTTGATTGATCATTTAACTGTGCTTGATAAGGCGAAGATGAAAGAAGTGGATACTGCACTTATAAT
TAGTTTAGGTTTATCAATCGATAGTGAATAG

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28582.94 Da        Isoelectric Point: 10.0870

>AT172817 WP_023328807.1 NZ_CP061700:c4891501-4890743 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLAFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTFSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp

>AT172817 NZ_CP079950:c2019500-2019360 [Macrococcus caseolyticus]
ATGAGCCAGAAGCTAGAACAAATGCTGATAGAAGGTTATCAATCAATGGCAGAGATAAATTTATCGATAGCATCAGAGCA
TTATGTATTAGAATGCGAAGTTACTGATAACCATCAGACATATACCTTTGATGGTGAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486LFH0

Antitoxin

Source ID Structure
AlphaFold DB A0A486Q3T7

References