Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4725301..4725817 Replicon chromosome
Accession NZ_CP061700
Organism Klebsiella pneumoniae strain C39

Toxin (Protein)


Gene name relE Uniprot ID R4YAY3
Locus tag IE968_RS22945 Protein ID WP_004178374.1
Coordinates 4725301..4725585 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag IE968_RS22950 Protein ID WP_002886901.1
Coordinates 4725575..4725817 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
IE968_RS22920 4720785..4721093 - 309 WP_012737232.1 PTS sugar transporter subunit IIB -
IE968_RS22925 4721178..4721351 + 174 WP_191072546.1 hypothetical protein -
IE968_RS22930 4721354..4722097 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
IE968_RS22935 4722454..4724592 + 2139 WP_004186701.1 anaerobic ribonucleoside-triphosphate reductase -
IE968_RS22940 4724833..4725297 + 465 WP_004222151.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
IE968_RS22945 4725301..4725585 - 285 WP_004178374.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
IE968_RS22950 4725575..4725817 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
IE968_RS22955 4725895..4727805 - 1911 WP_031593171.1 BglG family transcription antiterminator -
IE968_RS22960 4727828..4728982 - 1155 WP_002886900.1 lactonase family protein -
IE968_RS22965 4729049..4729789 - 741 WP_004186692.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11155.97 Da        Isoelectric Point: 10.3787

>T172816 WP_004178374.1 NZ_CP061700:c4725585-4725301 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESTRLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

>T172816 NZ_CP079950:c1226632-1226360 [Macrococcus caseolyticus]
ATGTCTAAGAAAAAGATACTTTTTTATTCAAGTGGTTTTGAAGATTATACGTACTGGCAAACTAACGATAAAACTGTATT
AAAGAAAATAAATAAACTAATAAAGAGTATTATGATTGATGGTGCGAATGAAGGCATAGGTAAGCCGGAAAAATTATTAG
GAAACTATACCGGTTGCTATAGCAGAAGGATCACTCATGAACATAGGCTCGTATATAAGATAGAAGATGATTCAATTTGT
ATTTTACAATGTCGTTTTCATTATAAAAGGTAG

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT172816 WP_002886901.1 NZ_CP061700:c4725817-4725575 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp

>AT172816 NZ_CP079950:c1226882-1226625 [Macrococcus caseolyticus]
ATGAAAGTTACAACTTATTCTAATGCAAGATCAAATTTTAGAAAAATAATAGATATTGTTAATGAAGATTGTGAACCTTA
CACAATAACAACAAATACACATAATGCCGTGATATTATCTGAACAAGATTATAATAGTATGATTGAAACACTTTATTTAC
AGAGTACACCAGCAAATGCCGAAAGATTACAAAAAGCGATTGATGAATCAATTGATAAAAATAACTTACTAGAAGTTGAG
ATAGATTTAGATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6THG1

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References