Detailed information of TA system TA172811

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 2681315..2682903
• Replicon: chromosome
• Accession: NZ_CP061700
• Organism: Klebsiella pneumoniae strain C39

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A486KW17
• Locus tag: IE968_RS13105
• Protein ID: WP_004190166.1
• Coordinates: 2681315..2682637 (-)
• Length: 441 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: A0A0H3GXD8
• Locus tag: IE968_RS13110
• Protein ID: WP_002904790.1
• Coordinates: 2682637..2682903 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
IE968_RS13090	2676371..2678872	+	2502	WP_004190161.1	fimbrial biogenesis outer membrane usher protein	-
IE968_RS13095	2678860..2679864	+	1005	WP_094986403.1	type 1 fimbrial protein	-
IE968_RS13100	2680006..2681298	+	1293	WP_002904794.1	glycoside hydrolase family 10 protein	-
IE968_RS13105	2681315..2682637	-	1323	WP_004190166.1	type II toxin-antitoxin system HipA family toxin	Toxin
IE968_RS13110	2682637..2682903	-	267	WP_002904790.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
IE968_RS13115	2683168..2683494	-	327	WP_004143476.1	hydroxyisourate hydrolase	-
IE968_RS13120	2683491..2683991	-	501	WP_004190169.1	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase	-
IE968_RS13125	2683969..2685348	-	1380	WP_004184021.1	purine permease	-
IE968_RS13130	2685694..2686848	+	1155	WP_191072529.1	FAD-dependent urate hydroxylase HpxO	-
IE968_RS13135	2686829..2687752	-	924	WP_004190172.1	LysR family hpxDE operon transcriptional regulator HpxR	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (4-103)

Antitoxin

• Cro/C1-type helix-turn-helix domain (16-65)

Sequences

Toxin

Protein

• Length: 441 a.a.
• Molecular weight: 49171.46 Da
• Isoelectric Point: 7.5357

>T172811 WP_004190166.1 NZ_CP061700:c2682637-2681315 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTTLLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIIATPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPREQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Nucleotide

• Length: 1323 bp

>T172811 NZ_CP079940:4417732-4417914 [Achromobacter sp. ES-001]
ATGAATAGCGCCGACATCATCAAACGACTAAAAGCGGATGGCTGGTATCTGGTGCACACAGTGGGCTCGCACCACCAGTT
CAAGCACCCCACCAAGCGCGGCAAGGTGACCGTGCCCCACCCGCGTAAAGATCTTCCAGTGCCGACAGCGCACAGTATCC
TCAAGCAAGCCGGCTTGAGGTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9906.27 Da
• Isoelectric Point: 8.5912

>AT172811 WP_002904790.1 NZ_CP061700:c2682903-2682637 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Nucleotide

• Length: 267 bp

>AT172811 NZ_CP079940:4417939-4418328 [Achromobacter sp. ES-001]
ATGCTTTATCCCATCTACGTACACAAAGAAAAGAGCAGCGCCTACGGAGCGTCTTTTCCGGACTTTCCGGGCTGCCACGC
AGCAGCAACCACGCTACAACGCCTGCCAGCCGCGGCACAGGAGGCGGTCGAAGCGCACTTCTTTGGCGAAACTGCACCCA
TCGCGCCGCCTACCGCGCCGGAGGTGTGGATACAAAAGAAGGCATTTAAAGGGGGCTTCTGGATGCTGGTCGACATCGAC
CTGTCCAAGGTCAACGCCAAGGCAGTCAGGCTTAATATCAGCTTGCCCGAAAATCTGGTGCATCGGATCGACGCGGTAGC
GCGGGCGCGGCGGCTGTCGCGCTCGGCTTTTCTGGCTCTGGCGGCACAACACGAAATGGAAGCGGCGTAG

Structures

Toxin

• AlphaFold DB: A0A486KW17

Antitoxin

• AlphaFold DB: A0A0H3GXD8