172798

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5997322..5999017 Replicon chromosome
Accession NZ_CP061699
Organism Pseudomonas aeruginosa strain LYSZa7

Toxin (Protein)


Gene name doc Uniprot ID A0A1C7C456
Locus tag LYSZa7_RS27720 Protein ID WP_022579703.1
Coordinates 5997322..5998191 (+) Length 290 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A7M3AXM3
Locus tag LYSZa7_RS27725 Protein ID WP_023108658.1
Coordinates 5998184..5999017 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LYSZa7_RS27695 5993330..5994181 + 852 WP_003130104.1 ABC transporter ATP-binding protein -
LYSZa7_RS27700 5994222..5995229 + 1008 WP_023106073.1 ABC transporter substrate-binding protein -
LYSZa7_RS27705 5995226..5996002 + 777 WP_003112898.1 ABC transporter permease -
LYSZa7_RS27710 5996008..5996769 + 762 WP_200200059.1 SDR family oxidoreductase -
LYSZa7_RS27715 5996783..5997313 + 531 WP_003112900.1 cupin domain-containing protein -
LYSZa7_RS27720 5997322..5998191 + 870 WP_022579703.1 alpha/beta hydrolase Toxin
LYSZa7_RS27725 5998184..5999017 + 834 WP_023108658.1 IclR family transcriptional regulator Antitoxin
LYSZa7_RS27730 5999004..5999801 + 798 WP_003112903.1 SDR family oxidoreductase -
LYSZa7_RS27735 5999794..6001476 + 1683 WP_200200060.1 thiamine pyrophosphate-binding protein -
LYSZa7_RS27740 6001487..6002290 + 804 WP_003112905.1 aspartate dehydrogenase -
LYSZa7_RS27745 6002302..6003786 + 1485 WP_023102925.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(41-272)

Antitoxin

Transcription regulator IclR, N-terminal

(16-66)


Sequences

Toxin        


Download         Length: 290 a.a.        Molecular weight: 30389.65 Da        Isoelectric Point: 6.8139

>T172798 WP_022579703.1 NZ_CP061699:5997322-5998191 [Pseudomonas aeruginosa]
MNMAQTHIPAPSLQQRFPERLVQLADGAQLAIRECGQGPVVVLLHGIGSGSASWLHCAQRLAAGNRVIAWDAPGYGLSTP
LPPARPKACDYAARLELLLDALGVESCLLVGHSLGALMATAYAAGIGAARVRRLVLLSPARGYGAAELRDSGAQVRRQRL
ENLERLGIDGMASERTARLLGRNPSEEALAWVRWNMARLNPEGYRQAVELLCGDDLLGNGQPAAPCEVHCGEDDGITTPE
SCGAIARQLGASFSPIPGAGHASPIEQPEVVAGRIGHAQRLSLEGTANG

Download         Length: 870 bp

>T172798 NZ_CP079933:c7281-6925 [Acinetobacter baumannii]
ATGTGGACAGTCATTACAACGGATCTGTTTAACGAATGGCTTGTACAGCAAGATGAATCTACACAAGAGAAAGTACTCGC
AGCGTTGGTCGTTCTACAGCAACAGGGACCAAGTTTAGGTCGTCCTTTAGTAGATACCGTCTATGACTCCAAATTTACCA
ACATGAAAGAGCTACGTGTTCAGCATCGAGGTAAACCACTGAGAGCCTTTTTCGCATTTGATCCTTTACGACAAGCTATT
GTGCTGTGTATCGGTGATAAAGGCGGTAAAAAGCGTTTTTATAAAGAGATGTTAGATATTGCCGATCAGCAATACGAACT
TCATCTTTCAACTTTAGGAGATCAATCTAATGGCTAA

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30819.22 Da        Isoelectric Point: 6.1414

>AT172798 WP_023108658.1 NZ_CP061699:5998184-5999017 [Pseudomonas aeruginosa]
MDKSDDSQDKYIVPGLERGLLLLCEFSRKDRTLTAPELARRLKLPRSTIFRLLTTLEAMGFVTRNGNEYRLGMAVLRLGF
EYLASLELTELGQPLLNRLCDEIRYPCNLVVRDGRSIVYVAKVSPSTPLSSSVNVGTRLPAHATVLGRILLQDLSLGELR
ELYPEEQLEQFSPNTPRSVLELFDMVQGDRQRGFVQGEGFFEASISTVAAPVRDHSGRVIAAMGATIAAGHIDPARIEGL
VSRVRSSADELSYLLDYRADGQDNVTPIFRSRPHETV

Download         Length: 834 bp

>AT172798 NZ_CP079933:c6932-6630 [Acinetobacter baumannii]
ATGGCTAAGACCCTACAAGAATTATTGGCTAGTCGCTCTCCAGAGAGTCAAGCTCGTATTCAAAAAATGGCTGATGAATT
ACTGTTGGAAACTCAGCTTCACCTTATTCGTGAAGAGTTAGAGATTTCTCAAAAAGAACTGGCTGCAACCCTTGGAATCA
AACAGCCGTCATTGTCAGCAATCGAAAATCGTGGTCATGATCTTAAAATTTCAACGATGAAAAAGTATGTTGAAGCAATG
GGCGGAAAACTTCGTATTGATGTAGAGCTTCCAACAGGAAAACACATAGGATTTAATGTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1C7C456

Antitoxin

Source ID Structure
AlphaFold DB A0A7M3AXM3

References